As a general principle, an infection should be treated with a single antibiotic. Combinations of antibiotics are only occasionally justified. The main bacteriological reasons for the use of combinations are:
To extend the spectrum of activity
To delay the development of resistance
To achieve synergy
KeywordsClavulanic Acid Fixed Combination Antibiotic Combination Cumulative Toxicity Optimal Agent
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© Springer-Verlag Berlin Heidelberg 1988