Combinations of Antibiotics

  • Sabine Enenkel
  • Wolfgang Stille


As a general principle, an infection should be treated with a single antibiotic. Combinations of antibiotics are only occasionally justified. The main bacteriological reasons for the use of combinations are:
  1. 1.

    To extend the spectrum of activity

  2. 2.

    To delay the development of resistance

  3. 3.

    To achieve synergy



Clavulanic Acid Fixed Combination Antibiotic Combination Cumulative Toxicity Optimal Agent 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Sabine Enenkel
    • 1
  • Wolfgang Stille
    • 2
  1. 1.Department of PediatricsUniversity Hospital, Johann Wolfgang Goethe-UniversitätFrankfurt/Main 70Germany
  2. 2.Department of Internal MedicineUniversity Hospital Johann Wolfgang Goethe-UniversitätFrankfurt/Main 70Germany

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