The principal objective in giving an antibiotic is to achieve a concentration at the site of infection which is sufficient to kill or inhibit the growth of the bacteria present. The dosage required to accomplish this object cannot always be defined in fixed terms; it often has to be adjusted to meet the special features of the individual case. Important factors which need to be taken into account are the sensitivity of the causative organism, the pharmacokinetics and tolerance of the antibiotic in relation to the patient’s age and illness, and the site of infection. The dose recommendations made by the manufacturers are sometimes also influenced by commercial considerations, with preference for underdosage (less expensive) or twice daily dosage (more convenient). Overdosage is less frequently recommended.
KeywordsNalidixic Acid Rheumatic Fever Causative Organism Fusidic Acid Pediatric Dosage
Unable to display preview. Download preview PDF.