Lung Xenografts as a Predictive Screen for Antineoplastic Agents
Inoculation of 337 human tumours of different types into nude mice resulted in tumour takes in 131 cases (39%). Tumour takes varied among the various tumour categories and the various histological types. From the 131 tumours growing in primary transplants, 80 tumours could be established as lines. In order to examine whether growth characteristics of untreated tumours in nude mice might be of prognostic significance for patient survival, the data from 171 non-small cell lung carcinoma xenografts were compared with the clinical data of the corresponding patients. Neither take rate nor establishment of a tumour line in nude mice was of prognostic value to the patient. In order to validate xenografts of human tumours as a predictive system, the antitumour activity of cyclophosphamide (CTX) and cisplatin (DDP) was tested against a panel of 14 human non-small lung tumour xenografts. The poor clinical response of lung tumours to CTX and DDP as reported in the literature is reflected in the lack of response of the tumour lines to these two agents.
KeywordsNude Mouse Lung Tumour Antitumour Activity Tumour Line Human Tumour Xenograft
Unable to display preview. Download preview PDF.
- 1.Sharkey FE, Fogh JM, Hajdu SI, Fitzgerald PJ and Fogh J: Experience in surgical pathology with human tumour growth in the nude mouse. In: Fogh and Giovanella (eds) The Nude Mouse in Experimental and Clinical Research 1978: 187–214 New York: Academic PressGoogle Scholar
- 2.Shorthouse AJ, Peckham MJ, Smyth JF and Steel GG: The therapeutic response of bronchial carcinoma xenografts: a direct patient-xenograft comparison. Br J Cancer 1980 (41) (Suppl) IV:142–145Google Scholar
- 3.Fogh J, Tiso J, Orfeo T, Sharkey FE, Daniels WP and Fogh JM: Thirty-four lines of six human tumour categories established in nude mice. J Natl Cancer Inst 1980 (61): 745–751Google Scholar