Pathophysiology of Hypertension in Diabetes Mellitus
There are many aspects to the relationships between hypertension and diabetes. These range from the question of whether elevated blood pressure is characteristic of those predisposed to develop noninsulin-dependent diabetes, as was suggested by one of the earlier epidemiologic studies of the incidence or development of diabetes , and if so, what is the underlying mechanism. More recently there are indications that blood pressure is elevated in persons with impaired glucose tolerance as defined by current diagnostic criteria, and that both impaired glucose tolerance and hypertension are associated with insulin resistance or reduced insulin-mediated glucose disposal as currently assessed by the euglycemic clamp technique . Furthermore, impaired glucose tolerance is associated with hyperinsulinemia and hypertriglyceridemia suggesting that there is a syndrome possibly with a common pathophysiologic basis that links these conditions .
KeywordsDiabetic Nephropathy Impaired Glucose Tolerance Albumin Excretion Rate Retinal Lesion Current Diagnostic Criterion
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- 10.Bennett PH, Rushforth NB, Miller M and LeCompte PM (1976) Epidemiological studies of diabetes in the Pima Indians. Ree Prog Hormone Res 32: 333–369Google Scholar
- 17.Krowlewski A, Rand L, Canesa L, Phillips L (1987) Genetic predisposition to hypertension is a risk factor for renal but not eye complications in IDD. Diabetes 36 (Suppl 1): 106 AGoogle Scholar