Vascular Damage in Hypertensive Rats

  • S. Kazda
Conference paper


In the natural history of the development of hypertension rats have problems with the elimination of sodium, in the initial phase. We speculated that this is probably due to increased renovascular resistance in the early stage, so that the rats probably need an increase in perfusion pressure to overcome this. They need to switch on the so-called pressure natriuresis. However, the increase in perfusion pressure is not without consequences. The blood pressure increase produces an autoregulatory vasoconstriction in the kidney, so that the renovascular resistance increases again (Fig. 1).


Perfusion Pressure Vascular Damage Salt Load Malignant Hypertension Heart Hypertrophy 
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© Springer-Verlag Berlin Heidelberg 1988

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  • S. Kazda

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