Special Lecture: The Role of Atrial Natriuretic Peptide in Cardiovascular and Renal Regulation in Man
The history of the development of this system is quite recent, although in the fifties, Dr. Kisch had already described electron dense granules in the atrial myocytes in guinea pigs; later they were found in many species, including man. In the late seventies, Dr. Marie and Dr. de Bold observed that the granularity in the atrial cells varies inversely with the state of hydration. In 1981, Dr. de Bold made the decisive experiment. He found that the injection of atrial tissue extracts into experimental animals had a natriuretic effect. This led to the successful identification and synthesis of peptides with 21 to 28 amino-aeid residues (Fig. 1), which have vasorelaxant and steroidogenesis-inhibiting properties in addition to their natriuretic effects. A propeptide with 126, and a pre-propeptide, which in humans has 151 amino acid residues, were also identified.
KeywordsNephrotic Syndrome Atrial Natriuretic Peptide Total Peripheral Resistance Atrial Myocytes Central Blood Volume
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- Weidmann P, Saxenhofer H, Ferner C, Shaw SG, Uehlinger D, Gnaedinger MP (1987) Atrial Natriuretic Peptide in Man. Am J Nephrol (in press)Google Scholar