Current Calcium Entry Blocker
The principle examples of the “first generation” of CEBs are verapamil, nifedipine and diltiazem. These three compounds are the reference standards against which new (and many older) compounds are compared. Each is a potent, and to varying degrees a selective CEB and, importantly, each has a distinct chemical structure. The differences in chemical structure give rise to differences in physical or chemical properties, distribution and metabolism, tissue binding characteristics and net biological effects. It is therefore not surprising that the therapeutic efficacy or tolerance of these agents may also be quite different (Sect. 4–5).
KeywordsCalcium Entry Myosin Light Chain Kinase Rabbit Aorta Vascular Contraction Antianginal Agent
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