Current Calcium Entry Blocker

  • Ronald D. Smith
  • Peter S. Wolf
  • John R. Regan
  • Stanley R. Jolly
Conference paper
Part of the Progress in Clinical Biochemistry and Medicine book series (PCBM, volume 6)

Abstract

The principle examples of the “first generation” of CEBs are verapamil, nifedipine and diltiazem. These three compounds are the reference standards against which new (and many older) compounds are compared. Each is a potent, and to varying degrees a selective CEB and, importantly, each has a distinct chemical structure. The differences in chemical structure give rise to differences in physical or chemical properties, distribution and metabolism, tissue binding characteristics and net biological effects. It is therefore not surprising that the therapeutic efficacy or tolerance of these agents may also be quite different (Sect. 4–5).

Keywords

Dihydropyridine Papaverine Dantrolene Loperamide Cyproheptadine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Ronald D. Smith
    • 1
  • Peter S. Wolf
    • 2
  • John R. Regan
    • 3
  • Stanley R. Jolly
    • 4
  1. 1.Department of Pharmaceutical ResearchDu Pont Critical CareWaukeganUSA
  2. 2.Sterling Drug, Inc.New YorkUSA
  3. 3.Rorer Central ResearchFort WashingtonUSA
  4. 4.East Carolina University, School of MedicineGreenvilleUSA

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