Central Nervous System Stimulants: Neuropharmacological Mechanisms

  • E. B. Nielsen
  • J. Scheel-Krüger
Part of the Psychopharmacology Series book series (PSYCHOPHARM, volume 4)


The mechanisms underlying CNS-stimulant drug discrimination are discussed. Although different doses of CNS stimulants may produce qualitatively different cues, it appears that a relatively low dose of d-amphetamine (e.g., 1 mg/kg) elicits a “general” CNS-stimulant cue. Presynaptically, this cue may primarily depend on release of endogeneous dopamine whereas inhibition of dopamine reuptake, per se, is insufficient to elicit the cue. Postsynaptically, the involvement of both dopamine D-1 and D-2 receptors is implicated. Furthermore, in the drug discrimination situation, D-1/D-2 receptors may be coupled differently than in dopamine-dependent locomotor activation. Anatomically, CNS-stimulant drug discrimination may depend primarily on mesolimbic dopamine systems.


Stereotyped Behavior Drug Discrimination Atypical Antipsychotic Drug Central Nervous System Stimulant Discriminative Stimulus Property 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. B. Nielsen
    • 1
  • J. Scheel-Krüger
    • 2
  1. 1.Pharmaceuticals R & D, Department of PharmacologyNOVO Industri A/SBagsvaerdDenmark
  2. 2.Psychopharmacological Research LaboratorySct. Hans Mental HospitalRoskildeDenmark

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