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Development of the Cholinergic Synapse: Role of Trophic Factors

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Book cover The Cholinergic Synapse

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 86))

Abstract

Considerable advances have been made in the last decade in the search for the trophic factors that might be operational during the development of cholinergic systems. The search has been inspired by the discovery of nerve growth factor (NGF), a protein essential for the development and maintenance of both sympathetic and sensory neurons, and various lines of experimental evidence suggesting the necessity of trophic factors for cholinergic neuron development. The use of tissue culture models has provided the technical means of approaching the problem and has now led to the purification of several factors that are putatively involved in various aspects of the development of cholinergic neurons in vivo. This chapter will focus on the work that has been directed to purifying the factors required for the survival and development of the cholinergic motor neurons of the parasympathetic nervous system and the spinal cord in vitro and, in view of its potential role in the expression of the cholinergic phenotype, on the factor purified from heart-cell conditioned medium that induces cholinergic characteristics in sympathetic neurons.

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  1. G. P. Richardson

    Present address: Ethology and Neurophysiology Group, School of Biology, University of Sussex, Brighton, Sussex, Great Britain

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  1. School of Biology, University of Sussex, Falmer, Sussex, UK

    G. P. Richardson

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  1. Arbeitsgruppe Neurochemie, Max-Planck-Institut für biophysikalische Chemie, Postfach 2841, D-3400, Göttingen, Germany

    Victor P. Whittaker

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Richardson, G.P. (1988). Development of the Cholinergic Synapse: Role of Trophic Factors. In: Whittaker, V.P. (eds) The Cholinergic Synapse. Handbook of Experimental Pharmacology, vol 86. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73220-1_5

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  • DOI: https://doi.org/10.1007/978-3-642-73220-1_5

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