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Thymic Hormones and Lymphocyte Functions

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The Pharmacology of Lymphocytes

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 85))

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Abstract

The differentiation of lymphocytes from precursor cells involves a complex series of events, and several factors control this sequential transformation of T cells. The thymic epithelium plays a central and apparently unique role in the first phases. It is during its direct contact with the thymic epithelium that the prothymocyte (whether or not it is already committed to the T cell lineage) is transformed into the immature cortical thymocyte, and eventually into the “post-thymic thymocyte.” This transformation is associated with the acquisition of antigenic markers, and the formation of the repertoire of anti-self receptors necessary for the cognitive functions of T cells (see Chap. 1).

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Authors
  1. J.-F. Bach
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  2. M. Dardenne
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Editor information

Editors and Affiliations

  1. Research Department, CIBA-GEIGY AG, CH-4002, Basel, Switzerland

    Michael A. Bray Ph. D.

  2. Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., CH-4002, Basel, Switzerland

    John Morley Ph. D., FRC Path.

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© 1988 Springer-Verlag Berlin Heidelberg

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Bach, JF., Dardenne, M. (1988). Thymic Hormones and Lymphocyte Functions. In: Bray, M.A., Morley, J. (eds) The Pharmacology of Lymphocytes. Handbook of Experimental Pharmacology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73217-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-73217-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73219-5

  • Online ISBN: 978-3-642-73217-1

  • eBook Packages: Springer Book Archive

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