Abstract
Although shigellosis is endemic throughout the world, it is of special concern in developing areas in which poor sanitation and low personal hygiene standards are responsible for a large number of cases. Children represent the major target of the disease, and malnutrition certainly accounts for the severity of the cases as well as a significant rate of mortality.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
La Brec EH, Schneider H, Magnani TJ, Formal SB (1964) Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J Bacteriol 88: 1503–1518
Formal SB, Hale TL, Sansonetti PJ (1983) Invasive enteric pathogens. Rev Infect Dis 5:5702–5707
Sereny B (1957) Experimental keratoconjunctivitis shigellosa. Acta Microbiol Acad Sci Hung 4:367–376
Formal SB, Kundel D, Schneider H, Kunev N, Sprinz H (1961) Studies with Vibrio c holerae in the ligated loop of the rabbit intestine. Br J Exp Pathol 42:504–510
Sansonetti PJ, Kopecko DJ, Formal SB (1982) Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect immun 35:852–860
Sansonetti PJ, Kopecko DJ, Formal SB (1981) Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect Immun 34:75–83
Sansonetti PJ, d’Hauteville H, Ecöbichon C, Pourcel C (1983) Molecular expression of virulence plasmids in Shigella and entero-invasive Esoheriohia coli. Ann Microbiol (Paris) 134 A:295–318
Sansonetti PJ, d’Hauteville H, Formal SB, Toucas M (1982) Plasmid mediated in- vasiveness of “Shigella-like” Esoheriohia coli. Ann Microbiol (Paris) 133:351–355
Sansonetti PJ, Hale TL, Dammin GI, Kapper C, Collins HH, Formal SB (1983) Alterations in the pathogenicity of Esoheriohia coli K12 after transfer of plasmid and chromosomal genes from Shigella flexneri. Infect Immun 39:1392–1402
Formal SB, Gemski P Jr, Baron LS, La Brec EH (1970) Genetic transfer of Shigella flexneri antigens to Esoheriohia coli K12. Infect Immun 1:279–287
Formal SB, Gemski P Jr, Baron LS, La Brec EH (1971) A chromosomal locus which controls the ability of Shigella flexneri to evoke keratoconjunctivitis. Infect Immun 3:73–79
Formal SB, La Brec EH, Kent TH, Falkow S (1965) Abortive intestinal infection with an Esoheriohia coli-Shigella flexneri hybrid strain. J Bacteriol 89:1374– 1382
Maurelli AT, Baudry B, d’Hauteville H, Hale TL, Sansonetti PJ (1985) Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri ,Infect Immun 49:164–171
Hale TL, Oaks EV, Formal SB (1985) Identification and antigenic characterization of virulence-associated, plasmid-coded proteins of Shigella spp. and enteroin- vasive Esoheriohia coli. Infect Immun 50:620–629
Sansonetti PJ, Ryter A, Clerc P, Maurelli AT, Mounier J (1986) Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid- mediated contact hemolysis. Infect Immun 51:461–469
Clerc PL, Ryter A, Mounier J, Sansonetti PJ (1987) Plasmid-mediated early killing of eukaryotic cells by Shigella flexneri as studied by infection of J774 macrophages. Infect Immun 55:521–527
Okamura N, Nakaya R (1977) Rough mutant of Shigella flexneri 2a that penetrates culture cells but does not evoke keratoconjunctivitis in guinea-pigs. Infect Immun 17:4–8
Kopecko DJ, Washington O, Formal SB (1980) Genetic and physical evidence of plasmid control of Shigella sonnei form I cell surface antigen. Infect Immun 29:207–214
Watanabe H, Timmis KN (1984) A small plasmid in Shigella dysenteriae 1 specifies one or more functions essential for O-antigen production and bacterial virulence. Infect Immun 43:391–396
Payne SM, Niesel DW, Peixotto SS, Lawlor KM (1983) Expression of hydroxamate and phenolate siderophores by Shigella flexneri. J Bacteriol 155:949–955
Griffiths E, Stevenson P, Hale TL, Formal SB (1985) Synthesis of aerobactin and a 76,000 dalton iron-regulated outer membrane protein by Escherichia coli ,K12- Shigella flexneri hybrids. Infect Immun 49:67–71
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sansonetti, P.J., Baudry, B., Clerc, P., Maurelli, A.T., Nassif, X., Ryter, A. (1987). Molecular Mechanisms of Pathogenicity in Shigella flexneri . In: Rott, R., Goebel, W. (eds) Molecular Basis of Viral and Microbial Pathogenesis. Colloquium der Gesellschaft für Biologische Chemie 9.–11. April 1987 in Mosbach/Baden, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73214-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-73214-0_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73216-4
Online ISBN: 978-3-642-73214-0
eBook Packages: Springer Book Archive