Abstract
The effects on paired-pulse and long-term potentiation of drugs which may affect memory have been investigated using rat hippocampal slices. Vincamine and lorazepam blocked long-term potentiation of the field EPSP and population spike recorded in subfield CA1. Vincamine reduced paired-pulse potentiation of the field EPSP. Lorazepam reduced, while vasopressin and pramiracetam increased the excitability of the population spike. These changes resulted in a variety of effects on paired-pulse potentiation of the population spike.
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© 1988 Springer-Verlag Berlin Heidelberg
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Brown, M.W., Riches, I.P., Cairns, N.J., Smithson, J.E. (1988). Memory-Affecting Drugs and Hippocampal Synaptic Plasticity. In: Haas, H.L., Buzsà ki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_43
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DOI: https://doi.org/10.1007/978-3-642-73202-7_43
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