Abstract
The role and organisation of the hippocampus not only gives us a unique opportunity to study the synaptic plasticity underlying LTP but also the changes in synaptic function associated with epilepsy. The kainic acid lesioned rat hippocampus has a pattern of cell loss that is similar to that found in temporal lobe epilepsy. In experiments using this chronic animal model of epilepsy we have observed changes in membrane and synaptic mechanisms that contribute to epileptiform bursting activity in the surviving CA1 pyramidal cells. The subject of this paper is to discuss the changes in inhibitory and excitatory synaptic function that underly this behaviour.
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References
Ashwood TJ, Wheal HV (1986a) Extracellular studies on the role of N-methyl-D-aspartate receptors in epileptiform activity recorded from the kainic acid lesioned hippocampus. Neurosci Lett 67: 147–152.
Ashwood TJ, Wheal HV (1986b) Loss of inhibition in the CA1 region of the kainic acid lesioned hippocampus is not associated with changes in the postsynaptic responses to GABA. Brain Res 367: 390–394.
Ashwood T J, Lancaster B, Wheal HV (1986) Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat. Exp Brain Res 62: 189–198
Ashwood TJ, Wheal HV (1987) The expression of an NMDA-receptor mediated component during epileptiform synaptic activity in the hippocampus. Brit. J. Pharm (In Press).
Collingridge GL, Kehl SJ, McLennan H (1983) Excitatory amino in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol 334: 33–46.
Cornish SM, Wheal HV (1986) The long term failure of inhibition in the chronic kainic acid model of temporal lobe epilepsy. Neurosci Lett Suppl 24: S36.
Davies SW, Ashwood TJ, Wheal HVF Kohler C (1985) Glutamate decarboxylase(GAD) and GAD immuno-reactivity(GDI) in the CA1 region of the kainic acid lesioned rat hippocampus. Neurosci Lett Suppl 21: S43.
Herron CE, Williamson R, Collingridge GL (1985) A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices. Neurosci Lett 61: 225–260.
Johnson JW, Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurones. Nature 325: 529–531.
Koerner JF, Cotman CW (1982) Response of Schaffer collateral CA1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids. Brain Res 251: 105–115.
Lancaster B, Wheal HV (1984) Chronic failure of inhibition in the CA1 area of the hippocampus following kainic acid lesions of the CA3/4 area. Brain Res 295: 317–324.
Meldrum BS, Croucher MJ, Badman G, Collins JF (1983) Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon Papio papis. Neurosci Lett 39: 101–104.
Newberry NR, Nicoll RA (1984) A bicuculline-resistant inhibitory post-synaptic potential in rat hippocampal pyramidal cells in vitro. J Physiol 348: 239–254.
Nowak L., Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462–465.
Ribak CE (1985) Axon terminals of GABAergic chandilier cells are lost at epileptic foci. Brain Res 326: 251–260.
Stelzer A, Slater NT, ten Bruggencate G (1987) Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy. Nature 326: 698–701.
Van Gelder NM, Sherwin AL, Rasmussen T (1977) Amino acid content of epileptogenic human brain: Focal versus surrounding regions. Brain Res 40: 385–397.
Watkins JC, Evans RH (1981) Excitatory amino acid transmitters. Ann Rev Pharm Toxicol 21: 165–204.
Wigstrom H, Gustafsson B (1984) A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro. Neurosci Lett 44: 327–332.
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© 1988 Springer-Verlag Berlin Heidelberg
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Wheal, H.V. (1988). Changes in Synaptic Function that Underly Epileptiform Activity in Hippocampal Pyramidal Cells. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_41
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DOI: https://doi.org/10.1007/978-3-642-73202-7_41
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