Abstract
Long-term potentiation (LTP) is a long-lasting facilitation of synaptic transmission which can be put in evidence after a tetanic stimulation of afferent fibers. The kindling process of stimulation, first described by Goddard consists in the application of a series of low intensity tetani to a brain structure such that after a number of repeated applications, after-discharges and epileptic seizures may occur. The question that we address here is how these two phenomena are related, namely whether kindling can be accounted for by an accumulation of LTP.
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References
Lopes da Silva, F.H. Hippocampal kindling: physiological evidence for progressive disinhibition. Advances in Epileptology, 1987, Vol. 16, Ch. 12: 57–62.
Melchers, B.P.C., Lopes da Silva, F.H. and Wadman, W.J. Long-term potentiation in the hippocampal slice: spatial aspects. In: H. Matthies (Ed.) Learning and memory: Mechanisms of information storage in the nervous system. Pergamon Press, Oxford, 1986: 51–60.
Kamphuis, W., Wadman, W.J., Buijs, R.M. and Lopes da Silva, F.H. Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy. Exp. Brain Res., 1986, 64: 491–495.
Kamphuis, W., Wadman, W.J., Buijs, R.M. and Lopes da Silva, F.H. The development of changes in hippocampal gamma-aminobutyric acid (GABA) in the rat kindling model of epilepsy: a light microscopic study with GABA-antibodies. Neuroscience, 1987a (in press).
Kamphuis, W., Lopes da Silva, F.H., and Wadman, W.J. Changes in local evoked potentials in the rat hippocampus (CAj) during kindling epileptogenesis. Brain Res., 1987b (in press).
Wadman, W.J., Heinemann, U., Konnerth, A. and Neuhaus, S. Hippocampal slices of kindled rats revealed calcium involvement in epileptogenesis. Exp. Brain Res., 1985, 57: 404–407.
Wadman, W.J., Melchers, B.P.C. and Lopes da Silva, F.H. Changes in spatial distribution of current sources and sinks during long-term potentiation in the in vitro fascia dentata of the rat 1987 (submitted for publication).
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© 1988 Springer-Verlag Berlin Heidelberg
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Lopes da Silva, F.H., Wadman, W.J., Kamphuis, W., Melchers, B.P.C., Pijn, J.P.M. (1988). Long-Term Potentiation in Relation to Kindling of the Rat Hippocampus. In: Haas, H.L., Buzsà ki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_39
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DOI: https://doi.org/10.1007/978-3-642-73202-7_39
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