Abstract
The third messenger protein kinase C (PKC) and the de novo synthesis of proteins are selectively involved in late phases of long-term potentiation (LTP), but not in its initiation. Whereas polymyxin B, an inhibitor of protein kinase C, blocked LTP 1–2 hours after tetanization, anisomycin, an inhibitor of protein synthesis, resulted in a blockade of LTP from 5–6 hours onward.
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© 1988 Springer-Verlag Berlin Heidelberg
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Reymann, K., Frey, U., Matthies, H. (1988). A Multi-Phase Model of Synaptic Long-Term Potentiation in Hippocampal CA1 Neurones: Protein Kinase C Activation and Protein Synthesis Are Required for the Maintenance of the Trace. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_37
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DOI: https://doi.org/10.1007/978-3-642-73202-7_37
Publisher Name: Springer, Berlin, Heidelberg
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