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Synaptic Plasticity in the Hippocampus pp 9–12Cite as

Changes in Synaptic Transmission Evoked in the “In Vitro” Hippocampal Slice by a Brief Decrease of [Mg++]0: A Correlate for Long-Term Potentiation?

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Abstract

Perfusion of hippocampal slices with Mg++ free Ringer for 20–30 min evoked an increased responsiveness of CA1 pyramidal cells to stratum radiatum stimulation up to 3 hours after reintroduction of the control Ringer. This potentiation was not observed when the NMDA antagonist APY (50–100uM) was present in the Mg++ free Ringer. However, once the potentiation has been initiated it was no longer affected by subsequent application of similar doses of APV.

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Author information

Authors and Affiliations

  1. Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montréal, Québec, Canada

    M. Avoli, C. Drapeau & G. Kostopoulos

Authors
  1. M. Avoli
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  2. C. Drapeau
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  3. G. Kostopoulos
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Editor information

Editors and Affiliations

  1. II. Physiologisches Institut, Johannes Gutenberg-Universität, Saarstrasse 21, 6500, Mainz, Germany

    Helmut L. Haas M.D.

  2. Department of Neurosciences MO24, University of California at San Diego, 92093, La Jolla, CA, USA

    György Buzsàki M.D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Avoli, M., Drapeau, C., Kostopoulos, G. (1988). Changes in Synaptic Transmission Evoked in the “In Vitro” Hippocampal Slice by a Brief Decrease of [Mg++]0: A Correlate for Long-Term Potentiation?. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-73202-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73204-1

  • Online ISBN: 978-3-642-73202-7

  • eBook Packages: Springer Book Archive

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