Collective Behaviors of the Hippocampal Slice — Epileptic and Nonepileptic
In this note, we shall review some experimental and computer-simulation results on neuronal population behaviors of the CA3 region in vitro. We are particularly interested in the phenomenon of synchronized neuronal bursting. Under what conditions can synchronization develop? Is disinhibition required? Can synchronization develop locally, and if so, what determines whether and at what velocity a synchronized event will propagate? These questions are important for understanding epilepsy, for the light they shed on synaptic actions and connectivity, and as a foundation for the investigation of experience-induced plasticity (since local tetanic stimulation leads to the development of synchrony within the tetanized region (Miles and Wong, in prep.)).
KeywordsSynaptic Potential Synaptic Inhibition Neuronal Burst Burst Propagation Inhibitory Conductance
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