Collective Behaviors of the Hippocampal Slice — Epileptic and Nonepileptic
In this note, we shall review some experimental and computer-simulation results on neuronal population behaviors of the CA3 region in vitro. We are particularly interested in the phenomenon of synchronized neuronal bursting. Under what conditions can synchronization develop? Is disinhibition required? Can synchronization develop locally, and if so, what determines whether and at what velocity a synchronized event will propagate? These questions are important for understanding epilepsy, for the light they shed on synaptic actions and connectivity, and as a foundation for the investigation of experience-induced plasticity (since local tetanic stimulation leads to the development of synchrony within the tetanized region (Miles and Wong, in prep.)).
KeywordsPenicillin Prep Haas Percolate Bicuculline
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- 3.MILES, R. and WONG, R.K.S. Unitary inhibitory synaptic potentials in the guinea-pig hippocampus in vitro. J. Physiol., Lond. 356: 97–113, 1984.Google Scholar
- 5.MILES, R. and WONG, R.K.S. Inhibitory control of local excitatory synaptic circuits in the guinea pig hippocampus. J. Physiol, Lond. in press.Google Scholar
- 9.TRAUB, R.D., MILES, R. and WONG, R.K.S. Models of synchronized hippocampal bursts in the presence of inhibition. I. Single population events. J. Neurophysiol in press.Google Scholar
- 10.TRAUB, R.D., MILES, R. and WONG, R.K.S. Studies of propagating epileptic events in the longitudinal hippocampal slice. Soc. Neurosci. Abstr. in press.Google Scholar
- 11.TRAUB, R.D., MILES, R., WONG, R.K.S., SCHULMAN, L.S. and SCHNEIDERMAN, J.H. Models of synchronized hippocampal bursts in the presence of inhibition. II. Ongoing spontaneous population events. J. Neurophysiol Google Scholar