Advertisement

Long-Term Potentiation in Slices from Human Hippocampus

  • H. L. Haas
  • R. W. Greene
  • B. Heimrich
  • X. Xie

Abstract

Long-term potentiation (LTP) has been observed in slices from human hippocampi removed for intractable epilepsy using extra- and intracellular recording in vitro. Furthermore the effects of several neuroactive substances with possible relevance for synaptic plasticity was investigated. Human hippocampal neurones in vitro display properties very similar to the respective rodent cells.

Keywords

Temporal Lobe Epilepsy Intracellular Recording Population Spike Synaptic Potential Perfusion Chamber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Griffith, W.H., Brown, T.H. & Johnston, D. (1986) Voltage-clamp analysis of synaptic inhibition during long-term potentiation in hippocampus. J. Neurophysiol. 55, 767–775.PubMedGoogle Scholar
  2. Haas, H.L. (1986) Long-term potentiation and intrinsic disinhibition. In: Learning and Memory: Mechanisms of information storage in the nervous system. Ed. H. Matthies, Advances in the Biosciences Vol. 59, 41–49, Pergamon, Oxford.Google Scholar
  3. H.L. Haas and R.W. Greene (1985) Long-term potentiation and 4-aminopyridine. Cell.Hoi.Neurobiol. 5, 297–301.CrossRefGoogle Scholar
  4. Haas, H.L. & Rose, G. (1982), Long-terra potentiation of excitatory synaptic transmission in the rat hippocampus: the role of inhibitory processes. J. Physiol. 329, 541–552.PubMedGoogle Scholar
  5. Haas, H.L. & Rose, G. (1984). The role of inhibitory mechanisms in hippocampal long term potentiation. Neurosci. Lett. 47, 301–306.PubMedCrossRefGoogle Scholar
  6. Haas, H.L., Scharer, B. & Vosmansky, M. (1979). A simple perfusion chamber for the study of nervous tissue slices in vitro. J. of Neuroscience Meth. 1, 323–325.CrossRefGoogle Scholar
  7. Haas, H.L., Wieser, H.G. and Yasargil, M.G. (1983). 4-Aminopyridine and fiber potentials in rat and human hippocampal slices. Experientia 39, 114–115.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. L. Haas
    • 1
    • 2
  • R. W. Greene
    • 1
    • 2
  • B. Heimrich
    • 1
    • 2
  • X. Xie
    • 1
    • 2
  1. 1.Neurochirurgische UniversitätsklinikZürichSwitzerland
  2. 2.Department of PhysiologyUniversity of MainzMainzFederal Republic of Germany

Personalised recommendations