Norepinephrine Enhances Long-Term Potentiation at Hippocampal Mossy Fiber Synapses

  • D. Johnston
  • W. F. Hopkins
  • R. Gray
Conference paper

Abstract

Mossy fiber synapses have a number of relatively unique features, one of which relates to the finding that long-term potentiation (DTP) at these synapses is not dependent on NMDA receptors (1). Norepinephrine (NE), through beta-adrenoceptors, can increase the magnitude, duration, and probability of induction of DTP at mossy fiber synapses. Results of experiments in which we injected cAMP analogs into the postsynaptic neuron and others in which we recorded the activity of single calcium channels suggest that the NE enhancement of LTP takes place postsynaptically through increased calcium influx.

Keywords

Norepinephrine NMDA HEPES Propranolol Haas 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. Johnston
    • 1
  • W. F. Hopkins
    • 1
  • R. Gray
    • 1
  1. 1.Program in NeuroscienceBaylor College of MedicineHoustonUSA

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