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Long-Term Potentiation of Feed-Forward Inhibition in Hippocampus: Extracellular Evidence

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Synaptic Plasticity in the Hippocampus

Abstract

A decrease in the slope of the EPSP-spike (E-S) relationship accompanies long-term potentiation (LTP) of the perforant path input to the dentate gyrus in normal, but not picrotoxin treated animals. When granule cell LTP is reduced by concurrent commissural tetanisation, a decrease in spike height and a shift to the right of the E-S curve is observed. Finally, short latency, low threshold units show a reduced firing threshold following perforant path tetanisation. These data are consistent with the hypothesis that LTP occurs at perforant path synapses onto feed-forward inhibitory interneurones.

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References

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Author information

Authors and Affiliations

  1. Department of Psychology and The Neuroscience Centre, University of Otago, Box 56, Dunedin, New Zealand

    G. V. Goddard, E. W. Kairiss, W. C. Abraham & D. K. Bilkey

Authors
  1. G. V. Goddard
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  2. E. W. Kairiss
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  3. W. C. Abraham
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  4. D. K. Bilkey
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Editor information

Editors and Affiliations

  1. II. Physiologisches Institut, Johannes Gutenberg-Universität, Saarstrasse 21, 6500, Mainz, Germany

    Helmut L. Haas M.D.

  2. Department of Neurosciences MO24, University of California at San Diego, 92093, La Jolla, CA, USA

    György Buzsàki M.D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Goddard, G.V., Kairiss, E.W., Abraham, W.C., Bilkey, D.K. (1988). Long-Term Potentiation of Feed-Forward Inhibition in Hippocampus: Extracellular Evidence. In: Haas, H.L., Buzsàki, G. (eds) Synaptic Plasticity in the Hippocampus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73202-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-73202-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73204-1

  • Online ISBN: 978-3-642-73202-7

  • eBook Packages: Springer Book Archive

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