Abstract
Dialysis perfusion has in a couple of years attained the position of a most promising approach to the biochemistry of cell to cell signalling in the brain. Still, sampling of fluid which has equilibrated with the tissue is an old tradition in neurochemical work. The dialysis concept advances the investigator one step further away from squirting Ringer’s medium on the brain. However, the in vivo monitoring of compounds in the extracellular space necessitates new considerations. Factors such as turnover and drainage of compounds form the extracellular fluid, sources of recruitment to the latter and thereby possible artifactual results, diffusion coefficients and changes in the extracellular volume become critical.
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Hamberger, A., Jacobson, I., Lehmann, A., Sandberg, M. (1988). Dynamics of the Cellular and Extracellular Compartment of Brain Amino Acids — Visions and Reality of the Dialysis Approach. In: Huether, G. (eds) Amino Acid Availability and Brain Function in Health and Disease. NATO ASI Series, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73175-4_8
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DOI: https://doi.org/10.1007/978-3-642-73175-4_8
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