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Gamma-Aminobutyric Acid as a Neurotrophic Agent

  • Conference paper
Amino Acid Availability and Brain Function in Health and Disease

Part of the book series: NATO ASI Series ((ASIH,volume 20))

Abstract

There is accumulating evidence that different classical neurotransmitters such as serotonin, catecholamines and the amino acid GABA may serve as epigenetic factors during neuronal development and differentiation (1, 2, 3, 4). Since a variety of macromolecular compounds, mainly peptides, are also known to act as neurotrophic factors (5) it is clear that the extremely complex processes which govern the development and differentiation of the neuronal network and communication system in the central nervous system are subject to regulation at a number of different levels. The present review will concentrate on a summary of the recent progress in studies concerned with the possible role of GABA and GABA agonists as agents stimulating neuronal development in vitro and in vivo.

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Author notes

  1. E. Meier

    Present address: Department of Pharmacology, H. Lundbeck & Co., LTD., DK-2500, Valby, Denmark

Authors and Affiliations

  1. Department of Biochemistry A, Panum Institute, University of Copenhagen, DK-2200, Copenhagen N, Denmark

    A. Schousboe, B. Belhage & G. H. Hansen

  2. Division of Neurosciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, 91010, USA

    R. Hammerschlag

Authors
  1. A. Schousboe
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  2. B. Belhage
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  3. E. Meier
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  4. R. Hammerschlag
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  5. G. H. Hansen
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Str. 3, 3400, Göttingen, Germany

    Gerald Huether

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© 1988 Springer-Verlag Berlin Heidelberg

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Schousboe, A., Belhage, B., Meier, E., Hammerschlag, R., Hansen, G.H. (1988). Gamma-Aminobutyric Acid as a Neurotrophic Agent. In: Huether, G. (eds) Amino Acid Availability and Brain Function in Health and Disease. NATO ASI Series, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73175-4_41

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  • DOI: https://doi.org/10.1007/978-3-642-73175-4_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73177-8

  • Online ISBN: 978-3-642-73175-4

  • eBook Packages: Springer Book Archive

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