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Synaptophysin: A Major Cell Type-Specific Vesicle Protein of Neuroendocrine Cells

  • Bertram Wiedenmann
  • Werner W. Franke
Conference paper
Part of the NATO ASI Series book series (volume 21)

Abstract

In recent years, three integral membrane proteins, which appear to be specifically associated with small (40–80 nm) vesicles with electron microscopically translucent contents have been detected in various neuroendocrine (NE) cells, primarily by the use of monoclonal antibodies. On SDS-polyacryl amide gel electrophoresis (PAGE) of proteins from brain tissue homogenates, these molecules appear with relative mobilities corresponding to Mr 95,000 (protein termed SV2; Buckley and Kelly, 1985), Mr 65,000 (Matthew et al., 1981) and Mr 38,000 (termed synaptophysin; Jahn et al., 1985; Wiedenmann and Franke, 1985). Particular progress has recently been made in our understanding of the molecular and cellular topology and distribution of synaptophysin.

Keywords

Synaptic Vesicle Neuroendocrine Cell Coated Vesicle Synaptic Vesicle Protein Presynaptic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Bertram Wiedenmann
    • 1
    • 2
  • Werner W. Franke
    • 1
    • 2
  1. 1.Med. Univ. Klinik, Department of MedicineUniversity of HeidelbergHeidelbergGermany
  2. 2.Institute of Cell and Tumor BiologyGerman Cancer Research CenterHeidelbergGermany

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