Properties of Presynaptic Voltage-Sensitive Calcium Channels in Rat Synaptosomes

Suszkiw, J. B.

doi:10.1007/978-3-642-73172-3_17

J. B. Suszkiw²

Part of the book series: NATO ASI Series ((ASIH,volume 21))

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Abstract

Voltage-sensitive calcium channels (VSCC) in presynaptic nerve terminals control influx of Ca²⁺ and thereby determine the quantity of transmitter released by presynaptic action potentials. Biochemical ⁴⁵Ca tracer flux experiments with isolated nerve endings (synaptosomes) indicate that K⁺-depolarization dependent ⁺Ca entry consists of fast transient and slow sustained components (Nachshen & Blaustein, 1980). This article summarizes recent studies from this laboratory, which indicate that the transient Ca influx represents a channel mediated process, whereas the sustained component reflects Ca entry via reversed Na/Ca exchange. The kinetic and pharmacological characteristics of the channel-mediated Ca influx (J_Ca) in rat cortical

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Authors and Affiliations

Department of Physiology and Biophysics, University of Cincinnati School of Medicine, Cincinnati, OH, 45267-0576, USA
J. B. Suszkiw

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J. B. Suszkiw
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Editors and Affiliations

AK Neurochemie, Zoologisches Institut der J. W. Goethe-Universität, Siesmayerstraße 70, 6000, Frankfurt am Main, Germany
Herbert Zimmermann

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Suszkiw, J.B. (1988). Properties of Presynaptic Voltage-Sensitive Calcium Channels in Rat Synaptosomes. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_17

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DOI: https://doi.org/10.1007/978-3-642-73172-3_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73174-7
Online ISBN: 978-3-642-73172-3
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