Abstract
The existence of presynaptic receptors at the releasing terminal level that mediate the modulation of transmitter release in the central nervous system is now well accepted. The nerve terminals of the central nervous system are also endowed with membrane transporters. It has been suggested that the main function of reuptake processes should be to remove the transmitter released previously into the synaptic cleft and to terminate its action at the postsynaptic receptors.
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References
Arbilla S, Larger SZ (1979) Facilitation by GABA of the potassium-evoked release of H-noradrenaline from rat occipital cortex. Naunyn-Schmiedeb Arch Pharmacol 306: 161–168
Balfour DJK (1980) Effects of GABA and diazepam on H-serotonin release from hippocampal synaptosomes. Eur J Pharmacol 68: 11–16
Bianchi C, Tanganelli S, Marzola G, Beani L (1982) GABA induced changes in acetylcholine release from slices in guinea-pig brain. Naunyn-Schmiedeb Arch Pharmacol 318: 253–258
Bonanno G, Raiteri M (1987a) Presence of -aminobutyric acid (GABA) uptake system on cholinergic terminals of rat hippocampus: evidence for neuronal coexistence of acetilcholine and GABA? J Pharmacol Exp Ther 240: 294–297
Bonanno G, Raiteri M (1987b) Regional selectivity of a -aminobutyric acid induced [H]acetilcholine release sensitive to inhibitors of -aminobutyric acid uptake. J Neurochem 48: 1454–1458
Bonanno G, Raiteri M (1987c) Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain. Br J Pharmacol 91: 237–243
Bonanno G, Raiteri M (1987d) Carriers for GABA and noradrenaline uptake coexist on a same nerve terminal in rat hippocampus. Eur J Pharmacol 136: 303–310
Bonanno G, Raiteri M (1987e) A carrier for GABA uptake exists on noradrenaline nerve endings in selective rat brain areas but not on serotonin terminals. J Neural Transmission 69: 59–70
Bowery NG, Hill DR, Hudson AL, Doble A, Middlemiss DN, Shaw J, Turnbull M, (1980) (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283: 92–94
Cuello AC (Ed) (1982) Co-transmission. Mac Millan Press 1982 New York
Enna SJ (Ed) (1984) The GABA receptors. Urnna Press 1984
Clifton, NY Ennis C, Cox B (1981) GABA enhancement of H dopamine release from slices of rat striatum: dependence on slice size. Eur J Pharmacol 70: 417–420
Fung SC, Fillenz M (1983) The role of pre-synaptic GABA and benzodiazepine receptors in the control of noradrenaline release in rat hippocampus. Neurosci Lett 42: 61–66
Giorguieff MF, Kernel ML, Glowinsky J, Besson MJ (1978) Stimulation of dopamine release by GABA in rat striatal slices. Brain Res 139: 115–130
Gray EG and Whittaker VP (1962) The isolation of nerve endings from brain: an electron microscope study of cell fragments derived by homogenization and centrifugation. J Anat 96: 79–87
Hokfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M (1980) Peptidergic neurons. Nature 284: 515–521
Marchi M, Hoffman DW, Giacobini E, Voile R (1981) Development and aging of cholinergic synapses. VI. Mechanisms of acetylcholine biosynthesis in the chick iris. Dev Neurosci 4: 442–450
Pittaluga A, Raiteri M (1987) Choline increases endogenous GABA release in rat hippocampus by a mechanism sensitive to hemicholinium-3. Naunyn-Schmiedeb Arch Pharmacol 336: 327–331
Raiteri M, Angelini F, Levi G (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur J Pharmacol 25: 411–414
Raiteri M, Levi G (1978) Release mechanisms for catecholamines and serotonin in synaptosomes. In: Ehrenpreis S, Kopin 1 (Eds). Reviews of Neuroscience, vol 3. Raven Press 1978 New York: 77–130
Reimann W, Zumstein A, Starke K (1982) aminobutyric acid can both inhibit and facilitate dopamine release in the caudate nucleus of the rabbit. J Neurochem 39: 961–969
Reubi JC, Emson PC, Jesell TM, Iversen LL (1978) Effects of GABA, dopamine, and substance P on the release of newly synthesized H-5-hydroxytryptamine from rat substantia nigra in vitro. Naunyn-Schmiedeb Arch Pharmacol 304: 271–275
Scatton B, Bartholini G (1981) GABA-Acetylcholine interaction in the rat striatum. In: Pepeu G, Ladinsky H (Eds). Cholinergic mechanisms. Plenum Press 1981 New York: 771–780
Smith JE, Lane JD, Shea PA, McBride WJ, Aprison MH (1975) A method for concurrent measurement of picomole quantities of acetylcholine, choline, dopamine, norepinephrine, serotonin, 5-hydroxytryptophan, 5-hydroxyindoleacetic acid, tryptophan, tyrosine, glycine, aspartate, glutamate, alanine and gamma-aminobutyric acid in single tissue samples from different areas of rat central nervous system. Anal Biochem 64: 149–169
Starr MS (1978) GABA potentiates potassium-stimulated 3H-dopamine release from slices of rat substantia nigra and corpus striatum. Eur J Pharmacol 48: 325–328
Starr MS (1979) GABA-mediated potentiation of amine release from nigrostriatal dopamine neurones in vitro. Eur J Pharmacol 53: 215–226
Stoof JC, Den Breejen EJS, Mulder AH (1979) GABA modulates the release of dopamine and acetylcholine from rat caudate nucleus slices. Eur J Pharmacol 57: 35–42
Yunger LM, Fowler PJ, Zarevics P, Setler PE (1984): Novel inhibitors of -aminobutyric acid (GABA) uptake: anticonvulsant actions in rats and mice. J Pharmacol Exp Ther 223: 109–115
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Raiteri, M., Bonanno, G., Pittaluga, A., Versace, P. (1988). Heterologous Carriers Located on Rat CNS Nerve Endings and their Possible Role in the Modulation of Transmitter Release. In: Zimmermann, H. (eds) Cellular and Molecular Basis of Synaptic Transmission. NATO ASI Series, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73172-3_12
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DOI: https://doi.org/10.1007/978-3-642-73172-3_12
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