Neural and Molecular Mechanisms of Short — and Long—Term Sensitization in Aplysia
A fundamental problem in neurobiology is to understand the basic processes that endow the nervous system with the ability to store and retrieve long-term memory. A related problem is to understand the relationship between the mechanisms for the induction, storage and retrieval of short-term memory and those for long-term memory. While behavioral studies of vertebrates indicate that short-term memory and long-term memory are distinct entities (Davis and Squire, 1984), there must be some mechanistic link between the two types, since short-term memories can be consolidated into long-term ones.
KeywordsMotor Neuron Sensory Neuron Test Stimulus Behavioral Sensitization cAMP Content
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- Baxter, D. A., Byrne, J. H. (1986) Serotonin- modulated membrane currents in Aplvsia tail sensory neurons. Soc. Neurosci. Abstr. 12: 765.Google Scholar
- Baxter, D. A., Byrne, J. H. (1987) Modulation of membrane currents and excitability by serotonin and cAMP in pleural sensory neurons of Aplvsia. Soc. Neurosci. Abstr. 13: 1440.Google Scholar
- Brunelli M., Castellucci V. F., Kandel E. R., (1976) Synaptic facilitation and behavioral sensitization in Aplvsia: Possible role of serotonin and cyclic AMP. Science 194: 1178– 1181.Google Scholar
- Byrne J. H. (1987) Cellular analysis of associative learning. Physiol. Rev. 67: 32- 439.Google Scholar
- Cleary, L. J., Byrne, J. H. (1986) Associative learning of the gill and siphon withdrawal reflex in Aplvsia: Interneurons mediating the unconditioned response. Soc. Neurosci. Abstr. 12: 397.Google Scholar
- Davis H. P., Squire L. R., (1984) Protein synthesis and memory: A review. Psvchol. Bull. 96: 518–559.Google Scholar
- Frost W. N., Castellucci V. F., Hawkins R. D., Kandel, E. R. (1985) Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplvsia participate in the storage of long-term memory for sensitization. Proc. Natl. Acad. Sci. USA 82: 8266–8269.PubMedCrossRefGoogle Scholar
- Pinsker H. M., Hening W. A., Carew T. J., Kandel, E. R. (1973) Long-term sensitization of a defensive withdrawal reflex in Aplvsia Science 182: 1039–1042.Google Scholar
- Schacher S., Castellucci, V. F., Kandel, E. R. (1987) Exogenous cycli AMP analog produces long-term facilitation of Aplvsia sensorimotor synapses in culture that is blocked by the protein synthesis inhibitor anisomycin. Soc. Neurosci. Abstr. 13: 390.Google Scholar
- Scholz K. P., Byrne J. H., (1987b) cAMP leads to long-term (24 hr) changes in membrane current in Aplvsia tail sensory neurons: A possible mechanism for long-term sensitization. Soc. Neurosci. Abstr. 13: 390.Google Scholar
- Walters E. T., Byrne J. H., Carew T. J., Kandel, E. R. (1983a) Mechanoafferent neurons innervating tail of Aplvsia. I. Response properties and synaptic connections. J. Neurophvsiol. 50: 1522–1542.Google Scholar
- Walters E. T., Byrne J. H., Carew T. J., Kandel, E. R. (1983b) Mechanoafferent neurons innervating tail of Aplvsia. II. Modulation by sensitizing stimulation. J. Neurophvsiol. 50: 1543–1559.Google Scholar