Abstract
For more than 70 years it has been known that porphyrins such as haematoporphyrin (HP) cause photosensitivity in man. The natural photosensitivity associated with the various porphyric diseases arises by a dysfunction of haem biosynthesis. Thus the photosensitivity associated with Gunther’s disease and erythropoietic protoporphyrin is due to an excess of a porphyrin, uroporphyrin (UP) and protoporphyrin (PP) respectively in these cases, in the skin. The ‘so-called’ haematoporphyrin derivative (HPD), sometimes as the commercial product Photofrin 1 or its somewhat refined version Photofrin 2, together with red light excitation has been used to treat over 6000 cancer patients worldwide, this treatment being known as photodynamic therapy (PDT).
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References
Jori G, Spikes JD., (1987) Photodynamic therapy of tumours and other diseases using porphyrins. Lasers in Med Science 2: 3–15
Boyle R, MacLennan AH, Maguire G, Keir WF, Truscott TG., (to be published) On the nature of the active component of haematoporphyrin derivative - Part II. Cancer Letts
Bonnett R, Charalambides AA, Land EJ, Sinclair RS, Tait D, Truscott TG., (1980) Triplet states of porphyrin esters. J C S Faraday Trans I 76: 852–859.
Bonnett R, Lambert C, Land EJ, Scourides PA, Sinclair RS, Truscott TG., (1983) The triplet and radical species of haematoporphyrin and some of its derivatives. Photochem Photobiol 38: 1–8
Reddi E, Jori G, Rodgers MAJ, Spikes JD., (1983) Flash photolysis studies of hemato- and copro-porphyrins in homogeneous and microheterogeneous aqueous dispersions. Photochem Photobiol 38: 639–645
Pottier R, Truscott TG., (1986) The photochemistry of haematoporphyrin and related systems. Int J Radiat Biol 50: 421–452
Lambert C, Rodgers MAJ, Jori G, Reddi E, Spikes JD., (1985) The photophysics of some liposome-bound porphyrins. In: Bensasson RV, Jori G, Land EJ, Truscott TG., (eds) Primary Photo-Processes in Biology and Medicine. Plenum Press, New York and London, p 325
Rodgers MAJ., (1985) The photoproperties of porphyrins in model biological environments. In: Jori G, Perria C., (eds) Photodynamic Therapy of Tumours and other Diseases. Libreria Progetto Editore, Padova, p 20
Truscott TG., (1986) The photochemistry of haematoporphyrin and some related species. J Chem Soc Faraday Trans 2 82: 2177–2181
Bielec J, Pilas B, Sarna T, Truscott TG., (1986) Photochemical studies of porphyrin-melanin interactions. J Chem Soc Faraday Trans 2 82: 1469–1474
Le Doan T, Perrouault L, Rougee M, Bensasson RV, Helene C., (1985) Singlet oxygen formation and cleavage of DNA photo-sensitised by porphyrins. In: Jori G, Perria C., (eds) Photodynamic Therapy of Tumours and other Diseases. Libreria Progetto Editore, Padova, p 55
Redmond RW., (1986) On the photophysical properties of haematoporphyrin and related species used in cancer phototherapy. Ph D Thesis CNAA (Paisley College)
McGarvey DJ, Morgan A, Truscott TG., (in preparation) Pulsed radiation studies of purpurins
Gorman AA, Hamblett J, Rodgers MAJ., (1984) Time resolved Luminescence measurements of triplet-sensitised singlet-oxygen production: variation in energy-transfer efficiences. J Am Chem Soc 106: 46 79–4682
Kellman A., (1977) Intersystem crossing and internal conversion yields of acridine in polar and non-polar solvents. J Phys Chem 81: 1195–1198
Pekkarinen L, Linschitz H., (1960) Studies on metastable states of porphyrins. II. Spectra and decay kinetics of tetraphenyIporphine, zinc tetraphenulporphine and bacteriochlorophyll. J Am Chem Soc 82: 2407–2411
Connolly JS, Gorman DS, Seely GR., (1973) Laser flash photolysis studies of chlorin and porphyrin systems. I. Energetics of the triplet state of bacteriochlorophyll. Ann N Y Acad Sci 206: 649–669
Connolly JS., (1978) Photophysical and photochemical properties of bacteriochlorophyll, Proc 2nd Int Conf of Photochemical Conversion and Storage of Solar Energy, Cambridge, UK
Drew Tait C, Holten D., (1983) Effects of Mg-solvent coordination state on some excited state processes of bacteriochlorophyll a. Photochem Photobiol 6: 201–209
Borland CF, Cogdell RJ, Land EJ, McGarvey DJ, Truscott TG., (1987) (in press) Photophysical studies of bacteriochlorophyll a and bacteriopheophytin a - singlet oxygen generation. J Photochem Photobiol
Krasnovsky AA, Jr., (1979) Photoluminescence of singlet oxygen in pigment solutions. Photochem Photobiol 29: 29–36
Redmond RW, Heihoff K, Braslavsky SE, Truscott TG., (1987) Thermal-1ensing and phosphorescence studies of the quantum yield and lifetime of singlet molecular oxygen (1Δg) sensitised by haematoporphyrin and related porphyrins in deuterated and non-deuterated ethanols. Photochem Photobiol 45: 209–213
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© 1988 Springer-Verlag Berlin Heidelberg
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Truscott, T.G. (1988). Photophysical and Related Aspects of Haematoporphyrin and Related Systems. In: Moreno, G., Pottier, R.H., Truscott, T.G. (eds) Photosensitisation. NATO ASI Series, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73151-8_49
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DOI: https://doi.org/10.1007/978-3-642-73151-8_49
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