Nerve Growth Factor Effects on CNS Cholinergic Neurons In Vivo
Levi-Montalcini’s discovery of Nerve Growth Factor (NGF) some 40 years ago has inspired dramatic changes in our perception of the nervous system as a highly regulated cell society. The concept that specific proteins (designated as neuronotrophic factors, or NTFs) are required for survival, growth and function of selected neuronal populations in the peripheral nervous system (PNS) during its development is being increasingly extended to the central nervous system (CNS) as well as to adult neurons in both PNS and CNS (Varon et al 1984; 1987a-d). If adult CNS neurons do depend throughout life on appropriately supplied NTFs, then it is possible to speculate that i) conditions leading to a deficient or defective NTF supply may be responsible for certain involutive or pathologic situations (Varon, 1975; Appel 1981), and/or ii) administration of exogenous NTFs could protect CNS neurons against such a deficit or alleviate their functional impairments.
KeywordsCorn Hydroxide Dementia Neurol Choline
Unable to display preview. Download preview PDF.
- Armstrong EM, Terry RD, DeTeresa RM, Bruce G, Hersh LB, Gage FH (1987) Response of septal cholinergic neurons to axotomy. J Comp Neurol, submittedGoogle Scholar
- Cotman CW (ed) (1978) Neuronal plasticity. Raven Press, New YorkGoogle Scholar
- Davis GE, Blaker SN, Engvall E, Varon S, Manthorpe M, Gage FH (1987a) Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science, in pressGoogle Scholar
- Davis GE, Engvall E, Varon S, Manthorpe M (1987b) Human amnion membrane as a substratum for cultured peripheral and central nervous system neurons. Dev Brain Res, in pressGoogle Scholar
- Davis GE, Klier, FG, Engvall E, Cornbrooks C, Varon S, Manthorpe M (1987c) Association of laminin with heparan and chondroitin sulfate-bearing proteoglycans in neurite-promoting complexes from rat Schwannoma cells. Neurochem Res, in pressGoogle Scholar
- Gage FH, Wictorin K, Fisher W, Williams LR, Varon S, Bjorklund A (1986b) Chronic intracerebral infusion of Nerve Growth Factor (NGF) improves memory performance in cognitively impaired aged rats. Soc Neurosci Abstr 12:1580Google Scholar
- Varon S (1975) In vitro approaches to the study of neural tissue aging. In: Maletta G (ed), Survey of the Aging Nervous System. DHEW Pub (NIH) 74–296, pp 59–76Google Scholar
- Varon S, Manthorpe M, Davis GE, Williams LR, Skaper SD (1987a) Growth Factors. In: Waxman SG (ed), Physiological Basis for Functional Recovery in Neurological Disease. Raven Press, in pressGoogle Scholar
- Varon S, Manthorpe M, Williams LR, Gage FH (1987b) Neuronotrophic factors and their involvements in the adult CNS. In: Terry R, Klier FG, Cornbrooks C (eds), Aging and the Brain. Raven Press, New York, in pressGoogle Scholar
- Varon S, Williams LR, Gage FH (1987c) Exogenous administration of neuronotrophic factors in vivo protects central nervous system neurons against axotomy induced degeneration. In: Seil FJ, Herbert E, Carlson BM (eds), Neural Regeneration. Progress in Brain Research, Vol 71, Elsevier, pp 191–201CrossRefGoogle Scholar
- Varon S, Williams LR, Gage FH (1987d) In vivo protection by an exogenous neuronotrophic factor against neuronal death in adult rat CNS. In: Masland R, Portera-Sanchez A, Toffano G (eds), Neuroplasticity: A New Therapeutical Tool in CNS Pathology. FIDIA Research Series, Liviana Press, Padova, Italy, in pressGoogle Scholar