Role of Nerve Growth Factor in Neuronal Injury and Survival

  • J. Regino Perez-Polo
  • K. Werrbach-Perez
Part of the NATO ASI Series book series (volume 22)


The response of the central and the peripheral nervous system to injury has several common elements. In particular, the population of molecules that serve as intercellular signals among neurons and glial elements is altered. The intracellular environment changes in response to the injurious event itself, directly, or to secondary events associated with the disruptive events and permeability changes at the interface of the endothelial barrier to the circulatory and lymphoid systems. It has been demonstrated for the hippocampal region of the CNS and the sciatic nerve in the PNS that injury results in synthesis, secretion and accumulation of neuronotrophic substances, and that glial cells proliferate and, with microglia in CNS or satellite cells in PNS, actively carry out phagocytosis and eventually participate in glial scar formation (Hendry, 1975; Nieto-Sampedro & Cotman, 1985; Rich et al, 1987).


Nerve Growth Factor Nerve Growth Factor Receptor Nerve Growth Factor Level Amino Acid Incorporation Glial Scar Formation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. Regino Perez-Polo
    • 1
  • K. Werrbach-Perez
    • 1
  1. 1.Department of Human Biological Chemistry and GeneticsUniversity of Texas Medical BranchGalvestonUSA

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