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Structure and Expression of ß-Nerve Growth Factor in the Rat Central Nervous System

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Neural Development and Regeneration

Part of the book series: NATO ASI Series ((ASIH,volume 22))

Abstract

Target-derived neuronal trophic factors have been implicated in the maturation and maintainance of both the central (CNS) and peripheral (PNS) nervous systems1-3 The most well characterized of these is β–nerve growth factor (NGF). The effects of NGF on PNS sensory and sympathetic neurons are well documented4,5 Present evidence suggests a physiological role for NGF also in the CNS. These data include the detection of molecules in the CNS with “NGF-like” physiological activity6-10 or immunological cross-reactivity9,11-15, as well as measurements of altered biological responses subsequent to injection of NGF or anti-NGF antibodies into the CNS16-25 Recent advances in recombinant DNA technology have allowed determination of NGF mRNA levels in the brain9,11,12,15,26-28. Finally, both the detection of specific NGF receptors in the CNS29-33 and the observed effects of NGF on cultured CNS neurons34-40 have supported a possible role of NGF in the CNS.

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Authors and Affiliations

  1. Department of Medical Genetics, Biomedical Center, Uppsala University, Box 589, S-751 23, Uppsala, Sweden

    Dr. Scott R. Whittemore, Håkan Persson, Ted Ebendal, Lena Lärkfors, Dan Larhammar & Anders Ericsson

  2. Department of Zoology, Uppsala University, S-751 23, Uppsala, Sweden

    Ted Ebendal & Lena Lärkfors

Authors
  1. Dr. Scott R. Whittemore
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  2. Håkan Persson
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  3. Ted Ebendal
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  4. Lena Lärkfors
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  5. Dan Larhammar
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  6. Anders Ericsson
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Editor information

Editors and Affiliations

  1. Istituto di Scienze Farmacologiche, Facoltà di Farmacia, Università di Milano, Via Balzaretti 9, 20129, Milano, Italy

    A. Gorio

  2. Department of Human Biological Chemistry and Genetics, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX, 77550, USA

    J. R. Perez-Polo

  3. Mental Retardation Research Center #68-177, Department of Anatomy and Department of Psychiatry and Biobehavioral Science, University of California, LA, 760 Westwood Plaza, Los Angeles, CA, 90024, USA

    J. de Vellis

  4. Department of Human Biological, Chemistry and Genetics and Department of Neurology, Marine Biomedical Institute, University of Texas Medical Branch, 200 University Blvd., #519, Galveston, TX, 77550, USA

    B. Haber

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© 1988 Springer-Verlag Berlin Heidelberg

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Whittemore, S.R., Persson, H., Ebendal, T., Lärkfors, L., Larhammar, D., Ericsson, A. (1988). Structure and Expression of ß-Nerve Growth Factor in the Rat Central Nervous System. In: Gorio, A., Perez-Polo, J.R., de Vellis, J., Haber, B. (eds) Neural Development and Regeneration. NATO ASI Series, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73148-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-73148-8_22

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