Advertisement

Gaba and Taurine as Signals for Neuronal Development and Differentiation

  • Arne Schousboe
  • Gert H. Hansen
  • Bo Belhage
  • Jens H. Abraham
  • Eddi Meier
Conference paper
Part of the NATO ASI Series book series (volume 22)

Abstract

During recent years evidence has been accumulating that different classical neurotransmitters such as serotonin, catecholamines and the amino acids GABA and taurine may serve as epigenetic factors during neuronal development and differentiation (Lauder,1983; Haydon et al.,1984; Konig et al., 1986; Redburn & Schousboe,1987). Since a variety of macromo- lecular compounds, mainly peptides, are also known to act as neurotrophic factors (Manthorpe et al., 1986) it is clear that the extremely complex processes which govern the development and differentiation of the neuronal network and communication system in the central nerve system are subject to regulation at a number of different levels. The present review will concentrate on a summary of the recent progress in studies concerned with the possible role of GABA and taurine as agents stimulating neuronal development.

Keywords

Gaba Receptor Cerebellar Granule Cell Gaba Agonist Neurotrophic Activity Gaba Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beart PM, Scatton B, Lloyd K (1985) Subchronic administration of GABAergic agonists elevates [3H]-GABA binding and produces tolerance in striatal dopamine catabolism. Brain Res 335:169–173PubMedCrossRefGoogle Scholar
  2. Belhage B, Meier E, Schousboe A (1986) GABA-agonists induce the formation of low affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA-receptors. Neurochem Res 11:599–606PubMedCrossRefGoogle Scholar
  3. Belhage B, Hansen GH, Schousboe A, Meier E (1987) The induction of low affinity GABA-receptors by GABA agonists on cerebellar granule cells is restricted to early development. Int J Devi Neurosci. SubmittedGoogle Scholar
  4. Curtis DA, Duggan AW, Felix O, Johnston GAR, McLennan H (1971) Antagonism between bicuculline and GABA in the rat brain. Brain Res 33:57–73PubMedCrossRefGoogle Scholar
  5. Drejer J, Larsson OM, Schousboe A (1982) Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Exp Brain Res 47:259–269PubMedCrossRefGoogle Scholar
  6. Drejer J, Larsson OM, Schousboe A (1983) Characterization of uptake and release processes for D- and L-aspartate in primary cultures of astrocytes and cerebellar granule cells. Neurochem Res 8:231–243PubMedCrossRefGoogle Scholar
  7. Falch E, Krogggaard-Larsen P (1982) The binding of the GABA agonist H-THIP to rat brain synaptic membranes. J Neurochem 38:1123–1129PubMedCrossRefGoogle Scholar
  8. Gallo V, Ciotti MT, Coletti A, Aloisi F, Levi G (1982) Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc Natl Acad Sci USA 79: 7919–7923PubMedCrossRefGoogle Scholar
  9. Hansen GH, Meier E, Schousboe A (1984) GABA influences the ultrastructure composition of cerebellar granule cells duri-ng development in culture. Int J Devi Neurosci 2: 247–257CrossRefGoogle Scholar
  10. Hansen GH, Meier E, Abraham JH, Schousboe A (1987a) Trophic effects of GABA on cerebellar granule cells in culture In: Redburn DA, Schousboe A (eds.): “Neurotrophic Activity of GABA During Development”, New York: Alan R. Liss, Inc., in pressGoogle Scholar
  11. Hansen GH, Belhage B, Schousboe A, Meier E (1987b) Temporal development of GABA-agonist induced alterations in ul- trastructure and GABA receptor expression in cultured cerebellar granule cells. Int J Devi Neurosci 5:in pressGoogle Scholar
  12. Haydon PG, McCobb DP, Kater SB (1984) Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons. Science 226:561–564PubMedCrossRefGoogle Scholar
  13. Hill DR, Bowery NG (1981) H-baclofen and H-GABA bind to bicuculline-insensitive GABAR sites in rat brain. Nature 290:149–152PubMedCrossRefGoogle Scholar
  14. Johnston GAR, Hailstone MH, Freeman CG (1980) Baclofen: Stereoselective inhibition of excitant amino acid release. J Pharm Pharmacol 32:230–231PubMedCrossRefGoogle Scholar
  15. Kato K, Goto M, Fukada H (1982) Baclofen: Inhibition of release of L-[3H]glutamate and L-[H]aspartate from rat whole brain synaptosomes. Gen Pharmacol 13:445–447PubMedCrossRefGoogle Scholar
  16. Konig N, Drian M-J, Privat A, Lamande N, Pares-Herbute N, Schachner M (1986) Dissociated cells of foetal rat pallium grown in culture medium supplemented with noradrenaline: Effects of the expression of neuron-specific enolase and cell adhesion molecule LI. Neurosci Lett 66:67–72PubMedCrossRefGoogle Scholar
  17. Lauder JM (1983) Hormonal and humoral influences on brain development. Psychoneuroendocrinology 8:121–155PubMedCrossRefGoogle Scholar
  18. Levi G, Gallo V (1981) Glutamate as a putative transmitter in cerebellum: Stimulation by GABA of glutamic acid release from specific pools. J Neurochem 37:22–31PubMedCrossRefGoogle Scholar
  19. Madtes PC, Bashir-Elahi R (1986) GABA receptor binding site ‘induction’ in rabbit retina after nipecotic acid treatment: Changes during development. Neurochem Res 11:55–61PubMedCrossRefGoogle Scholar
  20. Madtes PC, Redburn DA (1983a) GABA as a trophic factor during development. Life Sci 33:979–984PubMedCrossRefGoogle Scholar
  21. Madtes PC, Redburn DA (1983b) Synaptic interactions in the GABA system during postnatal development in retina. Brain Res Bull 10:741–745PubMedCrossRefGoogle Scholar
  22. Manthorpe M, Rudge JS, Varon S (1986) Astroglial cell contributions to neuronal survival and neuritic growth In: Fedoroff S, Varnadakis A (eds.) Astrocytes, Vol.2, New York: Academic Press, pp. 315–376Google Scholar
  23. McPherson GA (1983) A practical computer-based approach to the analysis of radioligand binding experiments. Comp Prog Biomed 17:107–114CrossRefGoogle Scholar
  24. Meier E, Schousboe A (1982) Differences between GABA receptor binding to membranes from cerebellum during postnatal development and from cultured cerebellar granule cells. Dev Neurosci 5:546–553PubMedCrossRefGoogle Scholar
  25. Meier E, Drejer J, Schousboe A (1983) Trophic actions of GABA on the development of physiologically active GABA receptors: In Mandel P, DeFeudis FV (eds): “CNS-Receptors from Molecular Pharmacology to Behaviour”, New York: Raven Press, pp 47–58Google Scholar
  26. Meier E, Drejer J, Schousboe A (1984) GABA induces functionally active low-affinitive GABA receptors on cultured cerebellar granule cells. J Neurochem 43:1737–1744PubMedCrossRefGoogle Scholar
  27. Meier E, Hansen GH, Schousboe A (1985) The trophic effect of GABA on cerebellar granule cells is mediated by GABA-receptors. Int J Devi Neurosci 3:401–407CrossRefGoogle Scholar
  28. Meier E, Belhage B, Drejer J, Schousboe A (1987a) The expression of GABA receptors on cultured cerebellar granule cell is influenced by GABA In: Redburn DA, Schousboe A, (eds.): “Neurotrophic Activity of GABA During Development”, New York: Alan R. Liss, Inc., in pressGoogle Scholar
  29. Meier E, Jorgensen OS, Schousboe A (1987b) Effect of repeated treatment with a GABA receptor agonist on postnatal neural development in rats. J Neurochem 49:in pressGoogle Scholar
  30. Mitchell R (1980) A novel GABA receptor modulates stimulus- induced glutamate release from cortico-striatal terminals. Eur J Pharmacol 67:119–122PubMedCrossRefGoogle Scholar
  31. Munson PI, Rodbard D (1980) A versatile computerized approach for characterization of ligand binding systems. Anal Biochem 107:220–239PubMedCrossRefGoogle Scholar
  32. Olsen RW (1981) GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem 37:1–13PubMedCrossRefGoogle Scholar
  33. Palacios JM, Young S, Kuhar MJ (1980) Autoradiographic localization of y-aminobutyric acid (GABA) receptors in the rat cerebellum. Proc Natl Acad Sci USA 77:670–674PubMedCrossRefGoogle Scholar
  34. Potashner SJ (1979) Baclofen: Effects on amino acid release and metabolism in slices of guinea pig cerebral cortex. J Neurochem 32:103–109PubMedCrossRefGoogle Scholar
  35. Redburn DA, Schousboe A (Eds)(1987) Neurotrophic Activity of GABA During Development. New York: Alan R. Liss,Inc., In pressGoogle Scholar
  36. Schousboe A (1982) Metabolism and function of neurotransmitters In: Pfeiffer S (ed.):“Neuroscience Approached Through Cell Culture” Vol.1, Boca Raton: CRC Press, pp. 107–141Google Scholar
  37. Schousboe A, Abraham JH (1987) Taurine induces low affinity GABA receptors on cerebellar granule cells. J Neurochem 48 Supl: S 104Google Scholar
  38. Schousboe A, Larsson OM, Krogsgaard-Larsen P (1985) Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain. Neurochem Int 7:505–508PubMedCrossRefGoogle Scholar
  39. Simantov R, Oster-Granite ML, Herndon RN, Snyder SH (1976) Gamma-aminobutyric acid (GABA) receptor binding selectively depleted by viral-induced granule cell loss in hamster cerebellum. Brain Res 105:365–371PubMedCrossRefGoogle Scholar
  40. Spoerri PE (1987) GABA-mediated developmental alterations in cultured neurons In: Redburn DA, Schousboe A (eds.): “Neurotrophic Activity of GABA During Development”, New York: Alan R. Liss, Inc., in pressGoogle Scholar
  41. Spoerri PE, Wolff JR (1981) Effect of GABA-administration on murine neuroblastoma cells in culture. Cell Tiss Res 218:567–579CrossRefGoogle Scholar
  42. Stone TW (1979) Glutamate as the neurotransmitter of cerebellar granule cells in the rat: Electrophysiological evidence. Int J Pharmacol 66:291–296Google Scholar
  43. Sturman JA, Moretz RL, French JH, Wisniewski HM (1985) Taurine deficiency in the developing cat: persistence of the cerebellar external granule layer. Prog Clin Biol Res 179:47–52Google Scholar
  44. Sykes C, Prestwich S, Horton R (1984) Chronic administration of the GABA-transaminase inhibitor ethanol amine O-sulphate leads to up-regulation of GABA binding sites. Biochem Pharmacol 33:387–393PubMedCrossRefGoogle Scholar
  45. Wang y3-J, Salvaterra P, Roberts E (1979) Characterization of H-muscimol binding to mouse brain membranes. Biochem Pharmacol 28:1123–1128CrossRefGoogle Scholar
  46. Wolff JR, Joo F, Dames W (1978) Plasticity in dendrites shown by continuous GABA administration in superior cervical ganglion of adult rat. Nature Lond 274:72–74PubMedCrossRefGoogle Scholar
  47. Young AB, Oster-Granite ML, Herndon RM, Snyder SH (1974) Glutamic acid: Selective depletion by viral induced granule cell loss in hamster cerebellum. Brain Res 73: 1–13PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Arne Schousboe
    • 1
  • Gert H. Hansen
    • 1
  • Bo Belhage
    • 1
  • Jens H. Abraham
    • 1
  • Eddi Meier
    • 1
  1. 1.Department of Biochemistry A, Panum InstituteUniversity of CopenhagenCopenhagen NDenmark

Personalised recommendations