Immune Suppression: An Integral Property of the Immune System?
Who sits at the T table, and how are they getting on with their careers? Well it’s always gratifying to meet the helper cell and his cousin the cytotoxic cell, both now at their prime, both with an excellent reputation for their benevolent work (in defending against disease), and both wearing as shiny buttons their newly discovered receptors. No problems there. And then there’s the antigen presenting cell also doing very well. He’s a Billy Bunter-ish figure, very greedy and has his buttons smeared with peptides. He too has his own accepted place at the table, and there is no hint of scandal in the offing. But there’s another member of the family with a far less satisfactory character. She’s been around for quite a time and doesn’t seem to be getting on nearly as well as had been hoped. In a Victorian sort of way she’s deemed to have past her prime. In molecular circles she’s considered disreputable, and the Yuppies won’t talk to her at all. What makes it worse is that she’s still having a lot of fun, and is not short of besotted admirers (me for instance). I refer, of course, to the suppressor T cell.
KeywordsMajor Histocompatibility Complex Helper Cell Cytotoxic Cell Imperial Cancer Research Fund T200 Peptide
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