Functions of the erbA and erbB Oncogenes in Avian Erythroblatosis

  • Björn Vennström
  • Hartmut Beug
  • Douglas Forrest
  • Ann Johnsson
  • Khash Khazaie
  • Alberto Munoz
  • Jan Sap
  • Axel Ullrich
  • Martin Zenke
Conference paper
Part of the NATO ASI Series book series (volume 26)

Abstract

The avian erythroblastosis virus (AEV) induces an acute erythro id leukemia and sarcomas in virus—infected chickens. AEV strain ES4 was isolated already during the thirties by Engelbreth-Holm by serial passage of a weak leukemia inducing virus (RAV1) in chicks. During the mid—seventies T. Graf demonstrated that a biologically cloned AEV causes both types of diseases, and transforms erythroblasts as well as fibroblasts in vitro.

Keywords

Toxicity Tyrosine Leukemia Sarcoma Prolactin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Björn Vennström
    • 1
  • Hartmut Beug
    • 1
  • Douglas Forrest
    • 1
  • Ann Johnsson
    • 1
  • Khash Khazaie
    • 1
  • Alberto Munoz
    • 1
  • Jan Sap
    • 1
  • Axel Ullrich
    • 2
  • Martin Zenke
    • 1
  1. 1.Differentiation ProgrammeEuropean Biology LaboratoryHeidelbergGermany
  2. 2.Genetech Inc.South San FranciscoUSA

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