Functions of the erbA and erbB Oncogenes in Avian Erythroblatosis
The avian erythroblastosis virus (AEV) induces an acute erythro id leukemia and sarcomas in virus—infected chickens. AEV strain ES4 was isolated already during the thirties by Engelbreth-Holm by serial passage of a weak leukemia inducing virus (RAV1) in chicks. During the mid—seventies T. Graf demonstrated that a biologically cloned AEV causes both types of diseases, and transforms erythroblasts as well as fibroblasts in vitro.
KeywordsEpidermal Growth Factor Receptor Ligand Binding Domain Erythroid Cell Thyroid Hormone Receptor Erythroid Differentiation
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