Effects of Cobalt, Indium, and Nickel on 7-Ethoxycoumarin-O-Deethylase in Mice
Cobaltous chloride is known to initiate a degradation of the hepatic microsomal cytochrome P450 content and consequently to depress the metabolic efficacy for the most xenobiotics. However, in mice after pretreatment with cobalt a paradox effect is observed with respect to metabolism of coumarin derivatives: the molecular activities towards coumarins are enhanced up to fourfold (Legrum et al. 1979; Hertle and Legrum 1980). In the living animal this increase overcompensates the loss of cytochrome P450, leading to a higher metabolism of coumarins than in controls (Legrum and Frahseck 1982). Similar inducing effects were observed after pretreatment with indium sulfate (Strack 1984; Mangoura et al. 1986).
KeywordsMicrosomal Protein Coumarin Derivative Cytochrome P450 Isozyme Cobaltous Chloride 10th European Workshop
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