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Effects of Cobalt, Indium, and Nickel on 7-Ethoxycoumarin-O-Deethylase in Mice

  • W. Legrum
  • S. A. Mangoura
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

Cobaltous chloride is known to initiate a degradation of the hepatic microsomal cytochrome P450 content and consequently to depress the metabolic efficacy for the most xenobiotics. However, in mice after pretreatment with cobalt a paradox effect is observed with respect to metabolism of coumarin derivatives: the molecular activities towards coumarins are enhanced up to fourfold (Legrum et al. 1979; Hertle and Legrum 1980). In the living animal this increase overcompensates the loss of cytochrome P450, leading to a higher metabolism of coumarins than in controls (Legrum and Frahseck 1982). Similar inducing effects were observed after pretreatment with indium sulfate (Strack 1984; Mangoura et al. 1986).

Keywords

Microsomal Protein Coumarin Derivative Cytochrome P450 Isozyme Cobaltous Chloride 10th European Workshop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • W. Legrum
    • 1
  • S. A. Mangoura
    • 1
  1. 1.Department of Pharmacology and ToxicologyPhilipps UniversityMarburgGermany

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