Effects of Adipates, Phthalates, and Fibrates on Liver Enzymes and Peroxisomes in a Variety of Mammalian Species

  • J. C. Lhuguenot
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)


More than 20 years ago, Hess et al. (1965) published their first paper on peroxisome proliferation in rat liver induced by Clofibrate, a hypolipidemic drug. During these past 22 years, peroxisome proliferation has become an intensive field of research field. The quite strong link between peroxisome proliferation and subsequent liver cancer is probably one of the major reasons for this enormous amount of work.


Peroxisome Proliferation Lipid Deposition Fenofibric Acid Diethylhexyl Phthalate Hepatic Peroxisome 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • J. C. Lhuguenot
    • 1
  1. 1.Départment de Biochimie et Toxicologie Alimentaires, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l’AlimentationCampus UniversitaireDijonFrance

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