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Effects of Puromycin Aminonucleoside on Ten Urinary Enzymes in Rats

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The Target Organ and the Toxic Process

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 12))

Abstract

A model of glomerular damage with tubular involvement is that induced by puromycin aminonucleoside (PAN). Extensive investigations of PAN nephrotoxicity by scanning and transmission electron microscopy have been performed (Andrews 1975; 1977; Carroll et al 1973), so that morphological events are described in detail. Comprehensive data on the effects on urinary enzymes are still lacking. The excretion of ten different enzymes was investigated in order to draw correlations with the reported ultrastructural alterations.

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References

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Author information

Authors and Affiliations

  1. Institute of Toxicology, Industrial Chemicals, BAYER AG, Friedrich-Ebert-Straße 217-333, D-5600, Wuppertal 1, Germany

    E. Bomhard

  2. Institute of Clinical Pathophysiology, BAYER AG, Friedrich-Ebert-Straße 217-233, D-5600, Wuppertal 1, Germany

    D. Maruhn

Authors
  1. E. Bomhard
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  2. D. Maruhn
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Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institute de Biologie Moléculaire et Cellulaire du Centre National de la Recherche Scientifique and Faculté de Pharmacie, Université Louis Pasteur, 15, rue René Descartes, 67084, Strasbourg, France

    Guy Dirheimer

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© 1988 Springer-Verlag

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Bomhard, E., Maruhn, D. (1988). Effects of Puromycin Aminonucleoside on Ten Urinary Enzymes in Rats. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_24

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  • DOI: https://doi.org/10.1007/978-3-642-73113-6_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18512-3

  • Online ISBN: 978-3-642-73113-6

  • eBook Packages: Springer Book Archive

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