Abstract
In long-term studies in rodents, focal hyperplasias of the thyroid, progressing to adenomas and follicular adenocarcinomas, are often observed. Many chemicals that induce these lesions interfere with thyroid hormone homeostasis, e.g., by inhibition of iodide trapping and oxidation, iodine organification, hormone secretion, protein binding, deiodination, and biliary excretion, followed by a compensatory secretion of thyrotropin (TSH). TSH increases the responsiveness of the thyroid to the mitogenic effect of polypeptide growth factor (Westermark et al. 1985; Polychronakos et al. 1986) and induces diffuse hyperplasia.
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References
Brown CG, Lee D, Atterill CK (1987) Phenobarbital and SK&F 93479-induced thyroid lesions in rats: correlation with changes in heaptic T4 metabolising enzyme activities, (abstr). British Endocrine Society Meeting, Warwick
Cavalieri RR, Pitt-Rivers R (1981) The effects of drugs on the distribution and metabolism of thyroid hormones. Pharmacol Rev 33:55–80
Colletta G, Cirafici AM, Vecchio G (1986) Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture. Science 233:458–460
Evarts RP, Brown CA (1980) 2,4-Diaminoanisole sulfate: early effect on thyroid gland morphology and late effect on glandular tissue of Fischer 344 rats. J N C I 65:197–204
Gerber H. Peter HJ, Studer H, Kaempf J (1986) Apparently clonal thyroid adenomas may contain heterogeneously growing and functioning cell subpopulations. Medeiros-Neto GA, Gaitan E (eds) New frontiers in thyroidology. Plenum, New York, pp 901–905
Hiasa Y, Kitahory Y, Konishi N, Enoki N, Fujita T (1984) Promoting effect of phenobarbital on N-bis(2-hydroxypropyl)nitrosamine thyroid tumorigenesis in rats. Effect of varying duration of exposure to phenobarbital. In: Börzsönyi M, Day NE, Lapis K, Yamasaki K (eds) Models, mechanisms and etiology of tumour promotion. International Agency for Research on Cancer, Lyon, pp 77–82. (IARC Scientific Publications 56)
Maier P, Schawalder HP (1986) A two-parameter flow cytometry protocol for the detection and characterization of the clastogenic, cytostatic and cytotoxic activities of chemicals. Mutat Res 164:269–379
Miloni E, Bürgi H, Studer H, Siebenhüner L, Lemarchand-Béraud T (1983) Thyroglobulin-rich colloid goitres: a result of the combined action of lithium and methimazole on the rat thyroid. Acta Endocrino (Copenh) 103:231–234
Napalkov NP (1976) Tumours of the thyroid gland. In: Tursov VS (ed) Pathology of tumours in laboratory animals, vol I. Tumours of the rat, part 2. International Agency for Research on Cancer, Lyon, pp 239–271 (IARC Scientific Publications 6)
Otto FJ, Oldiges H, Göhde W, Jain WK (1981) Flow cytometric measurement of nuclear DNA content variations as a potential in vivo mutagenicity test. Cytometry 2:189–191
Peter HJ, Studer H, Forster R, Gerber H (1982) The pathogenesis of “hot” and “cold” follicles in multinodular goiters. J Clin Endocrinol Metab 55:941–946
Polychronakos C, Guyda HJ, Patel B, Posner BI (1986) Increase in the number of type II insulin-like growth factor receptors during propylthiouracil-induced hyperplasia in the rat. Endocrinology 119:1204–1209
Scher, CD, Separd RC, Antoniades HN, Stiles CD (1979) Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochim Biophys Acta 560:217–241
Westermark K, Karlsson FA, Westermark B (1985) Thyrotropin modulates EGF receptor function in porcine thyroid follicle cells. Mol Cell Endocrinol 40:17–23
Westermark K, Westermark B, Karlsson FA, Ericson LE (1986) Location of epidermal growth factor receptors on porcine thyroid follicle cells and receptor regulation by thyrotropin. Endocrinology 118:1040–1046
Zbinden G (1987) Assessment of hyperplastic and neoplastic lesions of the thyroid gland. Trends Pharmacol Sci 8:511–514
Zbinden G, Maier P (1983) Single dose carcinogenicity of procarbazine in rats. Cancer Lett 21:155–161
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© 1988 Springer-Verlag
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Zbinden, G. (1988). Hyperplastic and Neoplastic Responses of the Thyroid Gland in Toxicological Studies. In: Chambers, P.L., Chambers, C.M., Dirheimer, G. (eds) The Target Organ and the Toxic Process. Archives of Toxicology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73113-6_15
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DOI: https://doi.org/10.1007/978-3-642-73113-6_15
Publisher Name: Springer, Berlin, Heidelberg
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