Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs

  • C. K. Atterwill
  • C. G. Brown
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)

Abstract

Thyroid function can be perturbed by agents affecting a number of processes involved in the thyroid endocrine homeostatic system (Fig. 1). These agents can affect function directly by interacting with thyroid cell receptors or their intracellular transduction mechanisms. Alternatively, thyroid function may be altered indirectly by agents affecting thyroid hormone metabolism, this event being followed by the release of thyrotrophic factors by feed back regulation, or by direct alterations in the release of these factors themselves from the pituitary gland (see also review by Cavalieri and Pitt-Rivers 1981).

Keywords

Adenoma Cimetidine Perchlorate Ranitidine Toxicology 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Atterwill CK, Collins P, Brown GG, Harland RF (1987) The Perchlorate discharge test for examining thyroid function in rats. J Pharmacol Methods (in press)Google Scholar
  2. Brown CG, Fowler K, Atterwill CK (1986) Assessment of thyrotoxicity using in vitro cell culture systems. Food Chem Toxicol 24:557–586PubMedCrossRefGoogle Scholar
  3. Brown CG, Lee DM, Jones CA, Atterwill CK (1988) Comparison of the effects of SKrF 93479 and Phenobarbitone (PB) treatment on thyroid toxicity and hepatic thyroid hormone metabolizing enzymes in the rat. Archives of toxicology (in press)Google Scholar
  4. Cavalieri RR, Pitt-Rivers R (1981) The effects of drugs on the distribution and metabolism of thyroid hormones. Pharmacol Rev 33:55–80PubMedGoogle Scholar
  5. Comer CP, Chengelis CP, Levin S, Kotsonis FM (1985) Changes in thyroidal function and liver UDP glucuronyltransferase activity in rats following administration of a novel imidazole (SC-37211). Toxicol Appl Pharmacol 80:427–436PubMedCrossRefGoogle Scholar
  6. Ekmann L, Hansson E, Havu N, Carlsson E, Lundberg C (1985) Toxicological studies on omeprazole. Scand J Gastroenterol 20:53–69CrossRefGoogle Scholar
  7. Hiasa Y, Kitahori Y, Ohshima M, Fujita T, Yuasa T, Konishi N, Miyashiro A (1982) Promoting effects of phénobarbital and barbital on development of thyroid tumours in rats treated with N-bis (2-hydroxypropyl) nitrosamine. Carcinogenesis 3:1187–1190PubMedCrossRefGoogle Scholar
  8. Hugues JN, Perret G, Sebaoun J, Modigliani E (1982) Effects of Cimetidine on thyroid hormones. Clin Endocrinol (Oxf) 17:297–302CrossRefGoogle Scholar
  9. Jones CA, Brown CG, Smith K, Atterwill CK (1986) In vitro models of the hypothalamic-pituitary system for studying drug toxicity. Food Chem Toxicol 24:811–812CrossRefGoogle Scholar
  10. Jones CA, Brown CG, Atterwill CK (1987) Thyroid toxicity and iodothyronine deiodination. Arch Toxicol [Suppl] 11:250–252Google Scholar
  11. Oppenheimer JH, Bernstein G, Surks MI (1968) Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phénobarbital. J Clin Invest 47:1399–1406PubMedCrossRefGoogle Scholar
  12. Oshima M, Ward JM (1984) Promotion of N-methyl-N-nitrosourea-induced thyroid tumours by iodine deficiency in F334/NCr rats. J Natl Cancer Inst 73:289–296Google Scholar
  13. Owen NV, Worth HM, Kiplinger GF (1973) The effects of long-term ingestion of methimazole on the thyroids of rats. Food Cosmet Toxicol 11:649–653PubMedCrossRefGoogle Scholar
  14. Pasquali R, Corincalderi R, Miglioli M, Melchionda N, Capelli M, Barbara L (1981) Effects of prolonged administration of ranitidine on pituitary and thyroid hormones, and their response to specific hypothalamic releasing factors. Clin Endocrinol (Oxf) 15:457–462CrossRefGoogle Scholar
  15. Rallison ML, Tyler FH, Kumagi LF (1964) Goitrous hypothyroidism induced by an anticonvulsant drug. J Pediatr 65:1085–1086CrossRefGoogle Scholar
  16. Saccomani G, Helander G, Crago S, Chang HH, Daley D, Sachs G (1979) Characterization of gastric mucosal membranes: X. immunological studies of gastric K+, H+-ATPase. J Cell Biol 83:271–283PubMedCrossRefGoogle Scholar
  17. Smeds S, Peters HJ, Jortso E, Gerber H, Studer H (1987) Naturally occurring clones of cells with high instrinsic proliferation potential within the follicular epithelium of mouse thyroids. Cancer Res 47:1646–1651PubMedGoogle Scholar
  18. Smith P, Wynford-Thomas D, Stringer BMJ, Williams ED (1986) Growth factor control of rat thyroid follicular cell proliferation. Endocrinology 119:1439–1445PubMedCrossRefGoogle Scholar
  19. Stringer, BMJ, Wynford-Thomas D, Williams ED (1985) In vitro evidence for an intracellular mechanism limiting the thyroid follicular cell growth reponse to thyrotropin. Endocrinology 116:611–615PubMedCrossRefGoogle Scholar
  20. Williams DW, Wynford-Thomas D, Williams ED (1987) Human thyroid adenomas show escape from IGF-1 dependence for growth. Ann Endocrinol (Paris) 48(2):11Google Scholar
  21. Wynford-Thomas D, Stringer BMJ, Williams ED (1982) Dissociations of growth and function in the rat thyroid during prolonged goitrogen administration. Acta Endocrinol (Copenh) 101:210–216Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • C. K. Atterwill
    • 1
  • C. G. Brown
    • 1
  1. 1.Smith Kline & French Research LtdThe Frythe, Welwyn, HertsUK

Personalised recommendations