Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs

  • C. K. Atterwill
  • C. G. Brown
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)


Thyroid function can be perturbed by agents affecting a number of processes involved in the thyroid endocrine homeostatic system (Fig. 1). These agents can affect function directly by interacting with thyroid cell receptors or their intracellular transduction mechanisms. Alternatively, thyroid function may be altered indirectly by agents affecting thyroid hormone metabolism, this event being followed by the release of thyrotrophic factors by feed back regulation, or by direct alterations in the release of these factors themselves from the pituitary gland (see also review by Cavalieri and Pitt-Rivers 1981).


Thyroid Follicular Cell Food Chem Toxicol Deiodinase Activity Thyroid Neoplasia Thyroid Toxicity 
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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • C. K. Atterwill
    • 1
  • C. G. Brown
    • 1
  1. 1.Smith Kline & French Research LtdThe Frythe, Welwyn, HertsUK

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