Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs
Thyroid function can be perturbed by agents affecting a number of processes involved in the thyroid endocrine homeostatic system (Fig. 1). These agents can affect function directly by interacting with thyroid cell receptors or their intracellular transduction mechanisms. Alternatively, thyroid function may be altered indirectly by agents affecting thyroid hormone metabolism, this event being followed by the release of thyrotrophic factors by feed back regulation, or by direct alterations in the release of these factors themselves from the pituitary gland (see also review by Cavalieri and Pitt-Rivers 1981).
KeywordsAdenoma Cimetidine Perchlorate Ranitidine Toxicology
Unable to display preview. Download preview PDF.
- Atterwill CK, Collins P, Brown GG, Harland RF (1987) The Perchlorate discharge test for examining thyroid function in rats. J Pharmacol Methods (in press)Google Scholar
- Brown CG, Lee DM, Jones CA, Atterwill CK (1988) Comparison of the effects of SKrF 93479 and Phenobarbitone (PB) treatment on thyroid toxicity and hepatic thyroid hormone metabolizing enzymes in the rat. Archives of toxicology (in press)Google Scholar
- Jones CA, Brown CG, Atterwill CK (1987) Thyroid toxicity and iodothyronine deiodination. Arch Toxicol [Suppl] 11:250–252Google Scholar
- Oshima M, Ward JM (1984) Promotion of N-methyl-N-nitrosourea-induced thyroid tumours by iodine deficiency in F334/NCr rats. J Natl Cancer Inst 73:289–296Google Scholar
- Williams DW, Wynford-Thomas D, Williams ED (1987) Human thyroid adenomas show escape from IGF-1 dependence for growth. Ann Endocrinol (Paris) 48(2):11Google Scholar
- Wynford-Thomas D, Stringer BMJ, Williams ED (1982) Dissociations of growth and function in the rat thyroid during prolonged goitrogen administration. Acta Endocrinol (Copenh) 101:210–216Google Scholar