Abstract
Except for metabolic emergencies and intoxications, critical states in medicine generally result from ischemia, thromboembolism, various types of shock, sepsis, and severe trauma. The most common clinical entities are myocardial infarction, postoperative embolic complications, septic shock, and multiple trauma with ensuing organ failure, in particular of the lungs and kidney. The prostaglandins (PGs) and thromboxane (TX) belong to a highly complex system of mediators, which in both research and clinical practice is believed to account for the numerous aspects of acute-phase host responses, ranging from disseminated intravascular coagulation to pulmonary edema.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Piper PJ, Vane JR, Wyllie JH (1970) Inactivation of prostaglandins by the lung. Nature 225: 600–604
Hyman AL, Spannhake EW, Kadowitz PJ (1978) Prostaglandins and the lung, state of the art. Am J Respir Dis 117: 11–136
Frölich JL, Ogletree M, Peskar BA, Brigham KL (1980) Pulmonary hypertension correlated to pulmonary thromboxane synthesis. In: Samuelsson B, Ramwell PW, Paoletti R (eds) Advances in prostaglandin and thromboxane research. Raven, New York, pp 745–750
Oettinger WKE, Walter GO, Jensen UM, Beyer A, Peskar BA (1983) Endogenous prostaglandin Fza in the hyperdynamic state of severe sepsis in man. Br J Surg 70: 237–239
Peskar BA, Anhut A, Kröner EE, Peskar BM (1975) Development, specificity and some applications of radioimmunoassays for prostaglandins and related compounds. In: Tillement JP (ed) Advances in pharmacology and therapeutics. Pergamon, Oxford, pp 275–286
Oettinger W, Peskar BA, Beger HG (1987) Profiles of endogenous prostaglandin Fla (PGF2a), thromboxane A2 (TXA2) and prostacyclin (PGI2) with regard to cardiovascular and organ functions in early septic shock in man. Eur Surg Res 19: 65–77
Gruber OF (1982) Prevention of fatal postoperative pulmonary embolism by heparin dihydroergotamine or dextran 70. Br J Surg 69: 54–58
Hirsch PD, Hillis CD, Campbell WD, Firth BG, Willerson JT (1981) Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. N Engl J Med 304: 685–689
Lewy RI, Weiner L, Walinsky P, Lefer AM, Silver MJ, Smith JB (1980) Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. Circulation 61: 1165–1168
Myers AK, Ramwell PW (1985) Thromboxane in sudden death. In: Neri GG, McGiff JC, Paoletti R, Born GVR (eds) Advances in prostaglandin, thromboxane and leukotriene research, Raven, New York, pp 81–88
Preston FE, Whipps S, Jackson CA, French AJ, Wyld PJ, Stoddard J (1981) Inhibition of prostacyclin and platelet thromboxane A2 after low-dose aspirin. N Engl J Med 304: 76–79
Alexander HR, Thompson WR, Ramwell PW, Fletcher JR (1985) Urinary thromboxane (TXA2) reflects the response to tissue injury in humans. Curr Surg 42: 18–20
Foegh ML, Winchester JF, Zmudka M, Helfrich GB, Ramwell PW, Schreiner GE (1982) Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection. Lancet ii: 48–49
Reines HD, Haluschka PV, Cook JA, Wise VC, Rambo V (1982) Plasma thromboxane concentrations are raised in patients dying with septic shock. Lancet 2: 174–175
Hechtman HB, Huval WV, Mathieson MA, Stemp LI, Valeri CR, Shepro D (1983) Prostaglandin and thromboxane mediation of cardiopulmonary failure. Surg Clin North Am 63: 263–283
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Oettinger, W., Beger, H.G. (1987). Prostaglandin, and Thromboxane Release in Critical States. In: Baethmann, A., Messmer, K. (eds) Surgical Research: Recent Concepts and Results. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73097-9_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-73097-9_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73099-3
Online ISBN: 978-3-642-73097-9
eBook Packages: Springer Book Archive