Advertisement

What is the action of sucralfate in the treatment of peptic esophagitis?

  • S. Bonfils
  • M. Dubrasquet
  • J. P. Galmiche
  • D. Cloarec
Conference paper

Abstract

Sucralfate is a basic saccharose sulfate of aluminium whose mode of action should prove of therapeutic value in reflux esophagitis with ulcerated lesions. It has been shown that this agent forms a complex with the proteins exposed by ulcerated gastric lesions, thereby adhering locally and constituting an effective barrier to the aggressive action of acid, pepsin and bile-salts.

Keywords

Gastric Acid Secretion Reflux Esophagitis Oesophageal Reflux Disease Taurocholic Acid Esophageal Ulceration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

References

  1. 1.
    Berges W, Sonnenberg A, Wienbeck M (1981) Sucralfat bei Reflux-osophagitis. Dtsch Med Wschr 106:853–854CrossRefGoogle Scholar
  2. 2.
    Eisborg L (1987) Oesophageal reflux disease: diagnosis, pathophysiology and treatment with special reference to the role of sucralfate. Scand J Gastroenterol 22 (supp 127): 101–109CrossRefGoogle Scholar
  3. 3.
    Goff JS, Adcock KA, Schmelter R (1986) Detection of esophageal ulcerations with technitium- 99m albumin sucralfate. J Nule Med 27:1143–1146Google Scholar
  4. 4.
    Kosawa K, Louineau F, Dubrasquet M, Bonfils S (1985) Effet du sucralfate sur l’évolution des lésions d’une œsophagite expérimentale chez le rat. Gastroenterol Clin Biol 9:111 A (résumé).Google Scholar
  5. 5.
    Laitinen S, Stahlberg M, Kairaluoma MI, Kiviniemi H, Paakkonen M, Lahtinen J, Poikolainen E, Aukee S (1985) Sucralfate and alginate/antacid in reflux esophagitis. Scand J Gastroenterol 20:229–232PubMedCrossRefGoogle Scholar
  6. 6.
    Schweitzer EJ, Bass BL, Johnson LF, Harmon JW (1985) Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology 88:611–619PubMedGoogle Scholar
  7. 7.
    Weiss W, Brunner H, Büttner GR, Gabot M, Miederer S, Mittelstaedt A, Olbermann M, Schwamberger K, Witzel L (1983) Therapie der Refluxösophagitis mit Sucralfat. Dtsch Med Wschr 108:1706–1711PubMedCrossRefGoogle Scholar

References

  1. 1.
    Brooks WS (1985) Sucralfate: non ulcer uses. Am J Gastroenterol, 80:206–209PubMedGoogle Scholar
  2. 2.
    Goff JS, Adcock KA, Schmelter R (1986) Detection of esophageal ulcerations with technetium 99m albumin sucralfate. J Nucl Med, 27:1143–1146PubMedGoogle Scholar
  3. 3.
    Orlando RC (1987) Cytoprotection by sucralfate in acid-exposed esophagus: a review Scand J Gastroenterol, 22 suppl 127:97–100Google Scholar
  4. 4.
    Schweitzer EJ, Bass BL, Johnson LF, Harmon JW (1985) Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology 88:611–619PubMedGoogle Scholar
  5. 5.
    Weiss W, Brunner H., Buttner G, Gabor M (1983) Therapie der reflux Ösophagitis sucralfat. DMW 108:1706–1711CrossRefGoogle Scholar
  6. 6.
    Carling L, Gronstedt J, Kagevi I et al. (1987) Sucralfate (sue) vs placebo in reflux esophagitis (RE). A double blind study. Gastroenterology 92:1338 (abstr)Google Scholar
  7. 7.
    Williams RM, Orlando RC, Bozymski EM et al. (1987) Multicenter trial of sucralfate suspension in the treatment of reflux esophagitis. Gastroenterology 92:1696 (abstr)Google Scholar
  8. 8.
    Laitinen S, Stahlberg M, Kairaludma MK et al. (1985) Sucralfate and alginate/antacid in reflux esophagitis. Scand J Gastroenterol 20:229–232PubMedCrossRefGoogle Scholar
  9. 9.
    Elsborg L (1987) Oesophageal reflux disease Scand J Gastroenterol 22 suppl 127:101–109Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Bonfils
    • 1
    • 2
  • M. Dubrasquet
    • 1
  • J. P. Galmiche
    • 2
  • D. Cloarec
    • 2
  1. 1.ParisFrance
  2. 2.Nantes, ParisFrance

Personalised recommendations