There is no demonstrated correlation between the severity of esophagitis and the concentration of biliary salts in the reflux fluid

  • E. Kivilaakso
Conference paper


Bile salts are alleged to be injurious to the esophageal mucosa and to promote esophagitis when refluxed into the esophagus. Especially the secondary bile salt, deoxycholate (DOCA), and in particular in its deconjugated form, has been incriminated, since DOCA is a highly potent detergent with widespread cytotoxic effects. It remains, however, obscure whether there is any correlation between bile salts in the reflux material and esophagitis. The present paper compares the contents of bile salts as well as bile salt composition in the reflux fluid with the severity of esophagitis, paying special emphasis to DOCA. The results are based on data published earlier [1].


Bile Acid Bile Salt Esophageal Mucosa Bile Acid Composition Gastric Mucosal Barrier 
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  1. 1.
    Matikainen M, Laatikainen T, Kalima T, Kivilaakso E (1982) Bile acid composition and esophagitis after total gastrectomy. Am J Surg 143:196PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • E. Kivilaakso
    • 1
  1. 1.HelsinkiFinland

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