Multiple Sclerosis: Phenotypic Immunogenetic Markers and Nucleic Acid Biochemistry

  • H. Zander
Conference paper


Twelve years ago, in 1974, the earliest use of the term “DNA probe” was made by Murphy and Attardi [19]. Since then, probes have rapidly propagated into every field of biology and medicine. In current practice, probes make it easier to determine genotype than phenotype. The approach to multiple sclerosis (MS) as proposed herein, although tremendously laborious, should provide the means of moving from linked marker genes to the very true genes that confer susceptibility to MS. The next step should be to sequence the susceptibility genes, to delineate their gene products — i.e., to identify the molecules that are involved in the pathogenesis — to studv their function, and — ultimately — to provide a molecular basis for therapy.


Multiple Sclerosis Spastic Paraparesis Definite Multiple Sclerosis Interferon Production Multiple Sclerosis Susceptibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • H. Zander
    • 1
  1. 1.Laboratory of Immunogenetics, KinderpoliklinikUniversity of MunichMunichGermany

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