Abstract
In recent years investigators have been oriented to consider multiple sclerosis (MS) as an immune or autoimmune disease. Occasional familial incidence strongly suggests the possible role of a genetic factor, and epidemiological data related to the incidence of MS within the kinship of the patients strongly supports MS heredity. Indeed [7] the incidence of MS is 7 times higher in first cousins, 12 times higher in parents, 22 times higher in brothers, 259 times higher in heterozygotes, and 535 times higher in monozygote twins. According to racial criteria, Caucasians are more affected than colored races [1–4].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Batchelor JR, Compston A (1978) The significance of the association between HLA and multiple sclerosis. Br Med Bull 34:279
Dupont T, Lisak RP, Hausen C et al. (1977) HLA antigens in black American patients with multiple sclerosis. Transpl Proc 9:181
Engell T, Raun NE, Thomsen M et al. (1982) HLA and heterogeneity of multiple sclerosis. Neurology 32:1043
Jersild C, Fog T, Hausen GS et al. (1973) Histocompatibility determinants in multiple sclerosis wi th special reference to the clinical course. Lancet ii: 1221
Stewart GT, McLead JG, Baten A et al. (1981) HLA family studies and multiple sclerosis: am common gene, dominantly expressed. Hum Immunol 3:13
Stewart GJ, Kirk RL (1983) The genetics of multiple sclerosis: the HLA system and other genetic markers. In: Hallpike GS, Adams CWM, Taurtellotta WW (eds) 1221 Multiple sclerosis: pathology, diagnosis and management. Chapman and Hall, London, Chap 4
Govaerts A, Gony J, Martin-Mondiere C et al. (1985) HLA and multiple sclerosis: population and families study. Tissue Antigens 25:187
McDonald WI, Halliday AM (1977) Diagnosis and classification of multiple sclerosis. Br Med Bull 33:4
Kurtzke JF (1961) On the evaluation of disability in multiple sclerosis. Neurology (Minneap) 11:696
Madigand M, Oger JJF, Fauchet R et al. (1982) HLA profiles in multiple sclerosis suggest two forms of disease and the existence of protective haplotypes. J Neurol Sci 53:519–529
Veneroni G, Pecora F, Cosi V et al. (1981) Antigeni HLA e miastenia grave. La Trasfusione Del Sangue 3:241
Wadia NG, Trikannad VS, Krishnaswamy PR (1980) Association of HLA-B12 with multiple sclerosis in India. Tissue Antigens 15:90
Trikannad VS, Wadia NH, Krishnaswamy PR (1982) Multiple sclerosis and HLA-B12 in Parsi and non-Parsi Indians. A clarification. Tissue Antigens 19:155
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Veneroni, G., Marforio, S., Rizzolo, L., Di Falco, M. (1988). HLA Studies in the Multiple Sclerosis Population. In: Cazzullo, C.L., Caputo, D., Ghezzi, A., Zaffaroni, M. (eds) Virology and Immunology in Multiple Sclerosis: Rationale for Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73032-0_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-73032-0_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73034-4
Online ISBN: 978-3-642-73032-0
eBook Packages: Springer Book Archive