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Calcium Antagonists in Silent Myocardial Ischemia — Preliminary Results with Nisoldipine

  • T. Meinertz
  • M. Zehender
  • H. Just
Conference paper

Summary

The use of calcium channel blockers was shown to be effective in the treatment of symptomatic and, more recently, of asymptomatic myocardial ischemia. In this continuing study we evaluated the efficacy of nisoldipine as a new calcium channel blocking agent in reducing the frequency and duration of episodes of silent myocardial ischemia. From the preliminary results in five patients, nisoldipine promises to treat episodes of silent myocardial ischemia effectively and thus to increase exercise tolerance.

Keywords

Holter Monitoring Silent Myocardial Ischemia Silent Ischemia Transient Myocardial Ischemia Unrecognized Myocardial Infarction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kannel WB, Abott RD (1984) Incidence and prognosis of unrecognized myocardial infarction: An update on the Framingham study. N Engl J Med 311: 1144–1147.PubMedCrossRefGoogle Scholar
  2. 2.
    Cecchi AC, Dovellinie EV, Marchi F, Pucci P, Santoro GM, Fazzini PF (1983) Silent ischemia during ambulatory electrocardiographic monitoring in patients with effort angina. J Am Coli Cardiol 1: 934–939.CrossRefGoogle Scholar
  3. 3.
    Cocco G, Braun S, Strozzi C, Leishman B, Chu D, Rochat N (1982) Asymptomatic myocardial ischaemia in patients with stable and typical angina pectoris. Clin Cardiol 5: 403–408.PubMedCrossRefGoogle Scholar
  4. 4.
    Cohn PF (1980) Silent myocardial ischemia in patients with a defective anginal warning system Am J Cardiol 45: 697–702.PubMedCrossRefGoogle Scholar
  5. 5.
    Resnelov L (1985) Silent myocardial ischemia: Therapeutic implications. Am J Med 79: 3A, 30–34.CrossRefGoogle Scholar
  6. 6.
    Schang SJ, Pepine CJ (1977) Transient asymptomatic ST-segment depression during daily activity. Am J Cardiol 39: 396–402.PubMedCrossRefGoogle Scholar
  7. 7.
    Deanfield JE, Shea M, Ribeiro P, Landsheere CM de, Wilson RA, Horlock P, Selwyn AP (1984) Transient ST-segment depression as a marker of myocardial ischemia during daily life. Am J Cardiol 54: 1195–1200.PubMedCrossRefGoogle Scholar
  8. 8.
    Chiariello M, Indolfi C, Cotecchia MR, Sifola C, Romano M, Condorelli M (1985) Asymptomatic transient ST changes during ambulatory ECG monitoring in diabetic patients. Am Heart J 110: 529–534.PubMedCrossRefGoogle Scholar
  9. 9.
    Stern S, Tzivoni D (1974) Early detection of silent ischemic heart disease by 24-hour electrocardiographic monitoring of active subjects. Br Heart J 36: 481–486.PubMedCrossRefGoogle Scholar
  10. 10.
    Wolf E, Tzivoni D, Stern S (1974) Comparison of exercise tests and 24-hour ambulatory electrocardiographic monitoring in detection of ST-T-changes. Br Heart J 36: 90–95.PubMedCrossRefGoogle Scholar
  11. 11.
    Hirzel HO, Leutwyler R, Krayenbuehl HP (1985) Silent myocardial ischemia: Hemodynamic changes during dynamic exercise in patients with proven coronary artery disease despite absence of angina pectoris. J Am Coli Cardiol 6: 275–284.CrossRefGoogle Scholar
  12. 12.
    Grossman W (1985). Why is left ventricular diastolic pressure increased during angina pectoris? JACC 5: 607–608.Google Scholar
  13. 13.
    Quyyumi AA, Mockus L, Wright C, Fox K (1985) Morphology of ambulatory ST-segment changes in patients with varying severity of coronary artery disease. Investigation of the frequency of nocturnal ischemia and coronary spasm. Br Heart J 53: 186–193.PubMedCrossRefGoogle Scholar
  14. 14.
    Silber S, Vogler A (1986) Die stumme Myokardischaemie: Dimensionierung eines Problems. Intensivmed 23,2: 52–63.Google Scholar
  15. 15.
    Deanfield JE, Spiegelhalter D (1987) Variability of myocardial ischemia in chronic stable angina. Eds.: Armin T, Maseri A. Silent ischemia, Springer Verlag Darmstadt, pp 177–181Google Scholar
  16. 16.
    Singh B (1986) A symposium: Detection, quantification and clinical significance of silent myocardial ischemia in coronary artery disease. Am J Cardiol 58: 3B.PubMedCrossRefGoogle Scholar
  17. 17.
    Bragg-Remschel DA, Anderson CM, Winkle RA (1982) Frequency response characteristics of ambulatory ECG monitoring systems and their implications for ST-segment analysis Am Heart J 103: 20–31.PubMedCrossRefGoogle Scholar
  18. 18.
    Bethge KP, Gonska BD (1985) ST-Segment-Analyse im Langzeit-Elektrokardiogramm: 1st die Methode ausgereift? Dtsch Med Wochenschr 26: 12023–1024.Google Scholar
  19. 19.
    Armin TH (1985) ST-Segmet-Analyse im Langzeit-EKG. Dtsch Med Wochenschr 110: 1047–1051.CrossRefGoogle Scholar
  20. 20.
    Brueggemann T, Andresen D, Erbherr G, Schroeder R (1986) Frequenzantwort verschiedener Langzeit-EKG-Systeme im Vergleich zum Standard-EKG. Z Kardiol, 75,4: 37.Google Scholar
  21. 21.
    Hubelbank, M, Feldman CL, Glasser SP, Clark PI, Polan BA (1984) ST-Analysis of Holter tapes. IEEE Computers in Cardiology, 269–272.Google Scholar
  22. 22.
    Shook TL, Balke W, Kotilainen PW, Selwyn AP, Stone PH (1986) Accuracy of detection of myocardial ischemia by amplitude-modulated and frequency-modulated Holter techniques. JACC 7,2: 104A.Google Scholar
  23. 23.
    Hubelbank M, Feldman CL, Kotilainen P (1985) The use of computer aided Holter monitoring for detection of ST-changes. IEEE Computers in Cardiology, 515–517.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • T. Meinertz
  • M. Zehender
  • H. Just

There are no affiliations available

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