The Regulation and Effects of Myometrial Activity on the Fetus

  • P. W. Nathanielsz
Conference paper

Abstract

In a review at the CIBA Foundation symposium meeting on The Fetus at Birth, in 1976, we described our early observations on the temporal relationships between myometrial contractures and fetal electrocorticogram (ECOG; Fig.1). We observed long-term epochs of myometrial contractility as reflected by an increased intrauterine pressure (IUP) lasting 5–15 min which we designated contractures to distinguish them from labor and delivery contractions. We stated that in several instances there was a suggestion that high amplitude fetal ECOG activity may in some way be temporally related to these contractures. Our early hypothesis was that contractures in some way affected the fetus either by decreasing oxygenation or by a sensory stimulus (Nathanielsz et al. 1976).

Keywords

Catheter Estrogen Cortisol Prostaglandin Rosen 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen D, Corbin J, Figueroa JP, Nathanielsz PW, Mitchell MD (1985) Inhibition of arachi-donic acid metabolism by antipyrine and 4-aminoantipyrine. Am J Obstet Gynecol 154: 420–423Google Scholar
  2. El Badry A, Figueroa JP, Poore ER, Sunderji S, Levine S, Mitchell MD, Nathanielsz PW (1984) Effect of fetal intravascular 4-aminoantipyrine infusions of myometrial activity (contractures at 125–143 days gestation in the pregnant sheep. Am J Obstet Gynecol 150: 474–481PubMedGoogle Scholar
  3. Figueroa JP, McDonald TJ, Nathanielsz PW, Poore ER, Wentworth RA (1985) Circadian variation in myometrial activity in the chronically instrumented pregnant sheep at 120–130 days gestation. J Physiol (Lond) 369:116P Google Scholar
  4. Fowden AL, Silver M (1983) The effect of the nutritional state on uterine prostaglandin F metabolite concentrations in the pregnant ewe during late gestation. Q J Exp Physiol 68: 337–349PubMedGoogle Scholar
  5. Fowden AL, Silver (1985) The effects of food withdrawal on uterine contractile activity and on plasma Cortisol concentrations in ewes and their fetuses during late gestation. In: Jones CT, Nathanielsz PW (eds) The physiological development of the fetus and newborn. Academic, London, pp 157–161Google Scholar
  6. Harbert GM (1977) Biorhythms of the pregnant uterus (Macaca mulatto). Am J Obstet Gynecol 129: 401–408PubMedGoogle Scholar
  7. Jansen CAM, Krane EJ, Thomas AL, Beck NFG, Lowe KC, Joyce P, Parr M, Nathanielsz PW (1979) Continuous variability of fetal PO2 in the chronically catheterized fetal sheep. Am J Obstet Gynecol 134: 776–783PubMedGoogle Scholar
  8. Milvae R, Mitchell MD, Nathanielsz PW, Pimentel G, Rosen ED (1986) The effect of food withdrawal on myometrial electromyographic (EMG) activity and maternal plasma concentrations of 13,14-dihydro-15-keto prostaglandin F (PGFM) and oestrone sulphate in the pregnant ewe at 122–127 days gestation (d G. A.). J Physiol (Lond): 41PGoogle Scholar
  9. Nathanielsz PW, Ratter S, Thomas AL, Rees L, Jack PMB (1976) The role and regulation of corticotropin in the fetal sheep. CIBA Found Symp 47: 73–91Google Scholar
  10. Nathanielsz PW, Frank D, Gleed R, Dillingham L, Poore ER, Figueroa JP (1984 a) Methods of investigation of the chronically instrumented pregnant rhesus monkey preparation maintained on a tether and swivel system. In: Nathanielsz PW (ed) Animal models in fetal medicine, vol 3. Perinatology Press, Ithaca NY, pp 110–160Google Scholar
  11. Nathanielsz PW, Jansen CAM, Yu HK, Cabalum T (1984 b) Regulation of myometrial function throughout gestation and labor: effect on fetal development. In: Beard RW, Nathanielsz PW (eds) Fetal physiology and medicine: the basis of perinatology. Perinatology Press, Ithaca NY, pp 629–653Google Scholar
  12. Nathanielsz PW, Poore ER, Brodie A, Taylor NF, Pimentel G, Figueroa JP, Frank D (1984 c) Update on molecular events of myometrial activity during pregnancy. In: Nathanielsz PW, Parer JT (eds) Research in perinatal medicine. Perinatology Press, Ithaca NY, pp 87–111Google Scholar
  13. Novy MJ, Walsh SW, Cook M J (1980) Chronic implantation of catheters and electrodes in pregnant nonhuman primates. In: Nathanielsz PW (ed) Animal models in fetal medicine, vol I. Perinatology Press, Ithaca NY, pp 133–168Google Scholar
  14. Pimentel G, Figueroa JP, Mitchell MD, Massmann A, Nathanielsz PW (1986) Effect of fetal and maternal intravascular antipyrine infusion on maternal plasma prostaglandin concentrations in the pregnant sheep at 104–127 days gestation. Am J Obstet Gynecol 155: 1181–1185PubMedGoogle Scholar
  15. Taylor NF, Martin MC, Nathanielsz PW, Seron-Ferre M (1983) The fetus determines the circadian oscillation of myometrial electromyographic activity in the pregnant rhesus monkey. Am J Obstet Gynecol 146: 557–567PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. W. Nathanielsz
    • 1
  1. 1.Laboratory for Pregnancy and Newborn Research, New York State College of Veterinary MedicineCornell UniversityIthacaUSA

Personalised recommendations