Abstract
Thorough reviews of the role of hormones in lung maturation are available (Ballard 1984; Smith 1984; Liggins and Schellenberg 1986) and will not be attempted in the present paper which has the purpose of examining recent information regarding the complex relationships of a number of hormones that interact either inside or outside the lungs to promote lung maturation. Many of the studies of hormonal effects on lung maturation in the past 15 years have been made in small laboratory animals which have certain disadvantages limiting their usefulness in dissecting hormonal interrelationships. In the first place, it is not possible to determine the concentrations of administered hormones or to ascertain the changes in other hormones that may occur as a result of treatment. Furthermore, the hormone must be administered either to the mother, in which case it is difficult to determine whether the observed effects are direct or indirect, or by a single injection into the fetus, in which case interpretation is confounded by responses to surgical stress. For these reasons, fetal sheep are being used more extensively, since in these animals the concentration of hormones can be measured serially and hormone treatments can be widely separated in time from operative stress. An added advantage of the larger, monotocous species is the ease of performing selective ablation of endocrine organs. This review will consider primarily work in sheep and will refer to similarities and differences in rats and rabbits only as appropriate.
This work was supported by the New Zealand Medical Research Council.
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© 1988 Springer-Verlag Berlin Heidelberg
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Liggins, G.C., Schellenberg, JC. (1988). Endocrine Control of Lung Development. In: Künzel, W., Jensen, A. (eds) The Endocrine Control of the Fetus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72975-1_20
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DOI: https://doi.org/10.1007/978-3-642-72975-1_20
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