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Experimental Evaluation of Chemoprophylaxis and Preventive Treatment in Animals

  • Chapter
Antituberculosis Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 84))

  • 127 Accesses

Abstract

The word prophylaxis is derived from the Greek phulaxis, which means “a guarding”. Properly speaking it should be applied only when speaking of diseases where infection can be prevented. However, in tuberculosis control we use the term BCG prophylaxis, although the bacillus Calmette-Guerin cannot prevent the tubercle bacillus from settling in a non-infected host: it can only prevent the further spread of infection. The terms primary chemoprophylaxis and secondary chemoprophylaxis have therefore been introduced, the first meaning protection from infection and the second prevention of the progression of infection to disease. In the control of tuberculosis the use of drugs on non-infected persons with the aim of preventing clinical disease or the spread of infection is practised widely. The terms chemoprevention, preventive therapy and chemoprotection are sometimes used instead of secondary prophylaxis. The U.S. Committee on Therapy used the term infection prophylaxis for primary prophylaxis, and disease prophylaxis for secondary prophylaxis.

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References

  • Allgood MA, Price GT (1971) Isoniazid therapy of tuberculosis in baboons. Primates 12:81–90

    Article  Google Scholar 

  • Andruschenko VV (1962) Chimioprofilaktyka tuberkul’ozu tvaryn. Socialist Tvaryunyctvo Kyiv 34:57

    Google Scholar 

  • Avellini G (1953) Compartamento del sangue periferico in bovini affetti da tuberculosi e trattati con idrazide dell’acido isonicotinico. Clin Vet (Milano) 76:361–381

    Google Scholar 

  • Badiali L (1954) L’idrazide dell’acido isonicotinico nella bovina, esperimento di profilassi tuberculosi. Vet Ital 5:7–18

    Google Scholar 

  • Badiali L, Baraccia E (1959) La chemioprofilassi nella tuberculosi bovina. Prime prove pratiche di risanamento. Vet Ital 10:292

    Google Scholar 

  • Badiali L, De Majo F (1962) Ulteriori ricerche sulla chimioprofilassi isoniazidica della tuberculosi bovina. Rev Tuberc Mal App Resp 10:3–30

    Google Scholar 

  • Bartmann K (1959) Isoniazid prophylaxis in exposed or minimally infected animals. Bull Int Union Tuberc 29:214–226

    Google Scholar 

  • Bartmann K (1960a) Die experimentellen Grundlagen der Chemoprophylaxe der Tuber-kulose mit Isonicotinsäurehydrazid (INH). Adv Tuberc Res 10:127–215

    Google Scholar 

  • Bartmann K (1960b) Weitere Untersuchungen über das Vaccinationsvermögen INH-resi-stenter BCG-Stämme. Beitr Klin Tuberk 123:132–138

    Article  CAS  Google Scholar 

  • Bartmann K (1962a) Die Prophylaxe der Tuberkulose durch BCG and Isoniazid, einzeln und in Kombination, bei Tier und Mensch. Tuberk Arzt 16:329–357

    CAS  Google Scholar 

  • Bartmann K (1962b) Formen und Indikationen der Chemoprophylaxe der Tuberkulose mit Isoniazid Tuberk Arzt 16:136–147

    Google Scholar 

  • Bartmann K, Blisse A (1967) Kurzfristige, primäre INH-Prophylaxe mit hohen Dosen bei minimal infizierten Meerschweinchen. Beitr Klin Tuberk 135:351–356

    Article  CAS  Google Scholar 

  • Bartmann K, Freise G (1963) Mikrobiologisch bestimmte INH-Konzentrationen im Gewebe von Tier und Mensch. Beitr Klin Tuberk 127:546–560

    Article  CAS  Google Scholar 

  • Bartmann K, Millberger H (1959) Das Vaccinationsvermögen INH-resistenter BCG-Stämme bei Meerschweinchen. Beitr Klin Tuberk 119:536–546

    Article  Google Scholar 

  • Bartmann K, Kleeberg HH, Spiess H (1971) Chemoprophylaxe und präventive Chemotherapie gegen Tuberkulose. In: Meissner G, Schmiedel A, Nelles A (Hrsg) Mykobakterien und mykobakterielle Krankheiten, Teil VIII. VEB Fischer, Jena, pp 277–311

    Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1955) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. I. Der Erfolg intermittierender Gaben von 10 mg INH je Kilogramm Körpergewicht im Simultanversuch an Meerschweinchen. Beitr Klin Tuberk 115:79–86

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1956) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. II. Der Erfolg zweimal wöchentlich verabfolgter Gaben von INH in verschiedener Dosierung beim Simultanversuch an Meerschweinchen. Beitr Klin Tuberk 115:269–275

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1957a) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. III. Prophylaktische Versuche mit INH an massiv infizierten Meerschweinchen. Beitr Klin Tuberk 116:471–478

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1957b) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. IV. Prophylaktische Versuche mit INH bei einer Minimalinfektion von Meerschweinchen. Beitr Klin Tuberk 116:687–698

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1957c) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. V. Virulenz-und Resistenzprüfungen von Kulturen aus Gewebe INH-behandelter Meerschweinchen. Beitr Klin Tuberk 117:344–349

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1958a) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. VI. Die Infektionsimmunität von Meerschweinchen bei einer prophylaktisch mit INH behandelten Tuberkulose. Beitr Klin Tuberk 118:87–101

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1958b) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. VII. Der Erfolg kontinuierlicher und intermittierender Gaben von INH und der Tripelkombination INH, Streptomycin, PAS im therapeutischen Versuch an Meerschweinchen. Beitr Klin Tuberk 118:297–313

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1958c) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. VIII. Der Bakteriengehalt des Gewebes minimal infizierter Meerschweinchen während der INH Prophylaxe. Beitr Klin Tuberk 119:75–84

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1959a) Tierexperimentelle Untersuchungen zu einer intermittierenden Chemotherapie und -prophylaxe der Tuberkulose. IX. Versuche an Meerschweinchen zur Prophylaxe einer Minimalinfektion mit kontinuierlichen und intermittierender INH-Gaben. Beitr Klin Tuberk 121:460–465

    Article  CAS  Google Scholar 

  • Bartmann K, Villnow J, Schwarz CH (1959b) Acquired resistance and isoniazid medication. Am Rev Tuberc 79:97–101

    CAS  Google Scholar 

  • Bjerkedal T, Palmer CE (1962) Effect of isoniazid prophylaxis in experimental tuberculosis in guinea pigs. Am J Hyg 76:89–123

    PubMed  CAS  Google Scholar 

  • Bjerkedal T, Palmer CE (1964) Effects of different concentrations of isoniazid on tubercle bacilli in guinea pigs. Acta Tuberc Scand 45:179–204

    CAS  Google Scholar 

  • Bloch H, Segal W (1955) Viability and multiplication of vaccines in immunization against tuberculosis. Am Rev Tuberc 71:228–248

    PubMed  CAS  Google Scholar 

  • Bretey J, Canetti G (1957) Vaccination par BCG normal et BCG isoniazido-résistant en présence et en absence d’un traitement par l’isoniazide. Ann Inst Pasteur 92:441–450

    CAS  Google Scholar 

  • Canetti G (1955) Une méthode de prophylaxie antituberculeuse associant la vaccination et la chimioprévention. Vaccination par le BCG isoniazido-résistant et administration d’isoniazide jusq’ à apparition de la résistance spécifique vaccinale. Rev Tuberc (Paris) 19:1392–1395

    CAS  Google Scholar 

  • Canetti G (1966) Wege zur Ausrottung der Tuberkulose. Prax Pneumol 19:602–610

    Google Scholar 

  • Canetti G, Grosset J (1958) L’influence du taux maximum d’INH libre du sérum sur la structure des souches isoniazido-résistantes apparaissant au cours de l’INH-thérapie. Rev Tuberc (Paris) 22:778–805

    Google Scholar 

  • Canetti G, Bretey J, Saenz A, Grosset J (1958) Effet d’un traitement précoce par l’isoniazide sur l’immunité engendrée chez un cobaye par une dose de BCG standard faible. Ann Irrst Past 95:262–271

    CAS  Google Scholar 

  • Castellani G, D’Esposito C, Zacchi B (1959) Quimioprofilaxis de la tuberculosis. Proc XVI`h Int Vet Congr (Madrid) 2:699–700

    Google Scholar 

  • Clarke GL, Schmidt JP (1969) Effect of prophylactic isoniazid on early developing ex-perimental tuberculosis in Macaca Mulatta. Am Rev Respir Dis 100:224–227

    PubMed  CAS  Google Scholar 

  • Cohn ML, Davis CL, Middlebrook G (1962) Chemoprophylaxis with isoniazid against aerogenic tuberculous infection in the guinea pig. Am Rev Respir Dis 86:95–97

    PubMed  CAS  Google Scholar 

  • Deborah Symposium (1959) Chemoprophylaxis of tuberculosis. Am Rev Respir Dis 80:1–139

    Google Scholar 

  • Debré R, Noufflard H, Foussereau S (1959) “Chimioprophylaxie” par l’isoniazide et immunité antituberculeuse. Contribution à l’étude expérimentale. Rev Fr Étud Clin et Biol 4:32–39

    Google Scholar 

  • Dickinson JM, Aber VR, Mitchison DA (1973) Studies on the treatment of experimental tuberculosis of the guinea pig with intermittent doses of isoniazid. Tubercle 54:211–224

    Article  PubMed  CAS  Google Scholar 

  • Dickinson JM, Mitchison DA (1976) Experimental investigations of bacteriological mechanisms in short course chemotherapy. Bull Int Union Tuberc 51:79–86

    PubMed  CAS  Google Scholar 

  • Didovets SR, Rotov VI, Chenurov KP (1978) Chemoprophylaxis of tuberculosis in cattle (using isoniazid). Veterinariya (Moscow, USSR) 10:50–57

    Google Scholar 

  • Domagk G, Offe HA, Siefken W (1952) Weiterentwicklung der Chemotherapie der Tuberkulose. Beitr Klin Tuberk 107:325–337

    Article  CAS  Google Scholar 

  • Ebina A (1959) Multiplication and antituberculosis immunity in mice by vaccination with BCG. Sci Rep Res Inst Tohoku Univ 8:455–467

    Google Scholar 

  • Ferebee SH, Palmer CE (1956) Prevention of experimental tuberculosis with isoniazid. Am Rev Tuberc 73:1–18

    PubMed  CAS  Google Scholar 

  • Franke R (1964) Erfahrungen mit INH-Dauertherapie zur Tuberkulose-Prophylaxe. T Diergeneesk 89 (Suppl):176–180

    Google Scholar 

  • Freerksen E (1956) Resistenz, Immunität, Allergie bei der Tuberkulose. Klin Wochenschr 34:881–887

    Article  PubMed  CAS  Google Scholar 

  • Freerksen E (1957a) Angeborene und erworbene Widerstandskraft bei der Tuberkulose. Tuberk Arzt 11:65–75

    CAS  Google Scholar 

  • Freerksen E (1957b) Discussion remarks. Bull Int Union Tuberc 27:220–221, 245–247

    Google Scholar 

  • Fust B, Studer A, Böhni E (1952) Experimentelle Erfahrungen mit dem Antituberkulotikum „Rimifon“. Schweiz Z Tuberk 9:226–242

    Google Scholar 

  • Gainsford W, Griffiths MI (1961) A freeze-dried vaccine from isoniazid-resistant BCG. Brit Med J 1:1500–1501

    Article  Google Scholar 

  • Grosset J (1978a) The sterilising value of rifampicin and pyrazinamide in experimental short course chemotherapy. Tubercle 59:287–297

    Article  Google Scholar 

  • Grosset J (1978b) Short course chemotherapy in experimental tuberculosis. Selected Papers 18:5–31

    Google Scholar 

  • Grumbach F (1962) Treatment of experimental murine tuberculosis with different combinations of isoniazid/streptomycin followed by isoniazid alone. Am Rev Respir Dis 86:211–215

    PubMed  CAS  Google Scholar 

  • Grumbach F (1965) Etudes chimiothérapiques de la tuberculose avancée de la souris. Adv Tuberc Res 14:31–96

    Google Scholar 

  • Grumbach F (1969) Experimental “in vivo” studies of new antituberculous drugs: capreomycin, ethambutol, rifampicin. Tubercle 50 (Suppl):12–21

    Article  PubMed  Google Scholar 

  • Grumbach F, Canetti G, Grosset J (1964) Further experiments on long-term chemotherapy of advanced murine tuberculosis, with emphasis on intermittent regimens. Tubercle 45:125–135

    Article  PubMed  CAS  Google Scholar 

  • Grumbach F, Canetti G, Grosset J, Le Lirzin M (1967) Late results of long-term, intermittent chemotherapy of advanced murine tuberculosis. Limits of the murine model. Tubercle 48:11–26

    Article  PubMed  CAS  Google Scholar 

  • Grumbach F, Canetti G, Le Lirzin M (1969) Rifampicin in daily and intermittent treatment of experimental murine tuberculosis, with emphasis on late results. Tubercle 50:280–293

    Article  PubMed  CAS  Google Scholar 

  • Grunberg E, Schnitzer RJ (1952) Studies on the activity of hydrazine derivates of isonicotinic acid on the experimental tuberculosis of mice. Quart Bull Sea View Hosp 13:311

    Google Scholar 

  • Hauser H (1963) Beitrag zur Tuberkulose-Morphologie bei Zoo-Ruminaten nach Rimifon-Behandlung. Schweiz Arch Tierheilkd 105:655–662

    Google Scholar 

  • Heilmeyer L (1952) Vorläufiger Bericht über Isonikotinsäurehydrazid (Rimifon, Neoteben) aufgrund experimenteller und klinischer Untersuchungen. Munch Med Wochenschr 94:1303–1308

    PubMed  CAS  Google Scholar 

  • Heymann H (1959) Use of isoniazid in zoo animals. Kleintierpraxis 4:123

    Google Scholar 

  • Hobby GL, Lenert TF, Rivoire ZC, Donikian M, Pikula D (1953) In vitro and in vivo activity of streptomycin and isoniazid singly and in combination. Am Rev Tuberc 67:808–827

    PubMed  CAS  Google Scholar 

  • Humbert R (1954) Biologische Heilung experimenteller Tuberkulose durch Isoniazid? Z Ges Exp Med 124:355–370

    Article  PubMed  CAS  Google Scholar 

  • Jankov M (1960) Immunization with BCG during the course of chemoprophylactic and chemotherapeutic treatment of guinea pigs infected with virulent tubercle bacilli. Bull Int Union Tuberc 30:123–132

    Google Scholar 

  • Jespersen A, Rasmussen KN (1955) Comparative studies on the effect of dihydrostreptomycin and isoniazid on immunised and non-immunised red mice following intravenous challenge with bovine tubercle bacilli. Acta Pathol Microbiol Scand 36:548–557

    Article  PubMed  CAS  Google Scholar 

  • Karlson AG, Feldman WH (1953) Effective therapeutic doses of isoniazid for experimental tuberculosis of guinea pigs. Am Rev Tuberc 68:75–81

    PubMed  CAS  Google Scholar 

  • Kikuth W, Pothmann FJ (1959) Zur Kombination von INH-Prophylaxe und BCG-Schutzimpfung. Dtsch Med Wochenschr 81:360–364

    Article  Google Scholar 

  • Khaikin B YA (1970) Chemoprophylaxis of tuberculosis in mink using isoniazid. Krolik Vod Zverovod 3:30

    Google Scholar 

  • Kleeberg HH (1959) The treatment of tuberculosis in man and animals with isoniazid. J S Afr Vet Med Assoc 30:69–73

    Google Scholar 

  • Kleeberg HH (1966) Chemotherapy and chemoprophylaxis of tuberculosis in cattle. Adv Tuberc Res 15:189–269

    Google Scholar 

  • Kleeberg HH (1967a) The use of chemotherapeutic agents in animal tuberculosis. Veterinarian (London) 4:197–211

    CAS  Google Scholar 

  • Kleeberg HH (1967b) Die Chemotherapie als neues Mittel zur Tilgung der Rindertuberkulose. Vet Med Nachr 2/3:223–239

    Google Scholar 

  • Kleeberg HH, Worthington RW (1963) A modern approach to the control of bovine tuberculosis. J S Afr Vet Med Assoc 34:383–391

    Google Scholar 

  • Kleeberg HH, Nixon RC, Worthington RW (1966) Evaluation of isoniazid in the field control of bovine tuberculosis. J S Afr Vet Med Assoc 37:219–228

    Google Scholar 

  • Kradolfer F (1970) Rifampicin, isoniazid, ethambutol, ethionamide and streptomycin in murine tuberculosis. Antibiot Chemother 16:352–360

    PubMed  CAS  Google Scholar 

  • Kubin M, Zavadilovà Z, Freslovà A (1959) Chemoprofylaxe pokusné tuberkulózy hydrazidem Kys. isonikotinové. Vet Med (Praha) 32:577–586

    Google Scholar 

  • Lambert HP (1959) The chemoprophylaxis of tuberculosis. Am Rev Respir Dis 80:648–658

    PubMed  CAS  Google Scholar 

  • Lambert HP (1960) The influence of chemoprophylaxis on immunity in experimental tuberculosis. Am Rev Respir Dis 82:619–626

    PubMed  CAS  Google Scholar 

  • Langenegger J, Langenegger CH, De Oliveira J (1981) Tratamento da tuberculosa bovina con isoniazida. Pesquisa Veterinaria Brasileira 1:1–6

    Google Scholar 

  • Lucchesi M, Spina G (1957) Basi sperimentali de la chemioprofilassi antitubercolare mediante isoniazide. Nota I: Riv Ital Tuberc 5:320–336

    CAS  Google Scholar 

  • Lucchesi M, Spina G (1958) Basi sperimentali de la chemioprofilassi antitubercolare mediante isoniazide. Nota II: Riv Ital Tuberc 6:103–130

    Google Scholar 

  • Lucchesi M, Spina G (1959) Basi sperimentali de la chemioprofilassi antitubercolare mediante isoniazide. Nota III: Riv Ital Tuberc 6:131–147

    Google Scholar 

  • Lucchesi M, Spina G (1960) Bases expérimentales de la chimioprophylaxie antituberculeuse par l’isoniazide. Bull Int Union Tuberc 30, 133–148

    Google Scholar 

  • Lucchesi M, Spina G (1961) Basi sperimentali de la chemioprofilassi antitubercolare mediante isoniazide. Nota IV: Riv Tuberc App Resp 9:42–56

    Google Scholar 

  • McCune R, Lee SH, Deuschle K, McDermott W (1957) Ineffectiveness of isoniazid in mod-ifying the phenomenon of microbial persistence. Am Rev Tuberc 76:1106–1109

    PubMed  CAS  Google Scholar 

  • Medoro GA, Rause G, Termine A (1960) Esperienze di chemio-vaccinoprofilassi con iso-niazide e BCG INH-resistente. Lotta C Tuberc 20:383–387

    Google Scholar 

  • Menemenli N, Eraslan A (1959) A pilot study on preventive and prophylactic effects of isoniazid in contact children. Bull Int Union Tuberc 29:259–266

    Google Scholar 

  • Moretti P, Pedini B (1953) Sulla attivatà preventiva antitubercolare nel vitello dell’idrazide dell’acido isonicotinico. Nuova Vet 28:315–322

    Google Scholar 

  • Nagata S (1958) Kekkaku 33:699–702

    PubMed  CAS  Google Scholar 

  • Nagata S (1959) Kekkaku 34:7–10, 552–555

    Google Scholar 

  • Nai DD, Perini G (1960) Ulteriori osservazioni sulla negativizzazione allergica dei bovini tuberculino-positivi trattati con isoniazide. Atti Soc Ital Sci Vet 14:612–616

    Google Scholar 

  • Nasta M, Algeorge G, Arhiri M, Negulescu VL (1957) Recherches sur la chimioprophylaxie de la tuberculose expérimentale du cobaye. Rev Tuberc (Paris) 21:1013–1017

    CAS  Google Scholar 

  • Nasta M, Algeorge G, Arhiri M (1960) Bases expérimentales de la chimioprophylaxie de la tuberculose. Bull Int Union Tuberc 30 No 2–3:149–156

    Google Scholar 

  • Nasta M, Arhiri M, Algeorge G (1960) Evolutia tuberculozei de suprainfectie la cobaii tuberculosi supusi chimioprofilaxei si chimioterapiei. Probl Tuberc (Bucuresti) 1:185–195

    Google Scholar 

  • Nitti V (1967) Activity of rifampicin in experimental tuberculosis of the guinea pig. Chemotherapia 12:369–400

    Article  CAS  Google Scholar 

  • Omodei-Zorini A (1963) La chemioprofilassi antitubercolare mediante isoniazide in campo umano e bovine. Ann Ist Forlanini 23 (Suppl):227–423

    Google Scholar 

  • Omodei-Zorini A (1963) Further developments in human and bovine antituberculosis chemoprophylaxis with isoniazid in Italy. Dis Chest 43:131–141

    Article  Google Scholar 

  • Palmer CE (1959) The effect of isoniazid on experimental tuberculosis in the guinea pig. Bull Int Union Tuberc 29:273–275

    Google Scholar 

  • Palmer CE, Ferebee SH, Hopwood L (1956) Studies on the prevention of experimental tuberculosis with isoniazid. II. Effects of different dosage regimens. Am Rev Tuberc 74:917–939

    PubMed  Google Scholar 

  • Peizer LR, Chaves AD, Widelock D (1957) The effects of early isoniazid treatment in experimental guinea-pig tuberculosis. Am Rev Tuberc 76:732–751

    PubMed  CAS  Google Scholar 

  • Rosati T, Tini R (1955) Sull’andamento della reazione in bovini naturalmente infetti e trattati con idrazide dell’acido isonicotinico. Vet Ital 6:895–905

    Google Scholar 

  • Rosati T, Badiali L (1959) La chemioprofilassi della tuberculosi bovina mediante isoniazide. Riv Tuberc App Respir 7:207–227

    Google Scholar 

  • Rosati T, Badiali L (1960) Investigations on antituberculous chemoprophylaxis and comparative tests with BCG vaccination. Am Rev Respir Dis 82:577–578

    PubMed  CAS  Google Scholar 

  • Schaefer WB, Cohn ML, Middlebrook G (1957) Comparative study of the vaccinating properties of BCG and its isoniazid-resistant mutant in guinea pigs. Am Rev Tuberc 75:656–658

    PubMed  CAS  Google Scholar 

  • Schmidt LH (1956) Some observations on the utility of simian pulmonary tuberculosis in defining the therapeutic potentialities of isoniazid. Am Rev Tuberc 74 Suppl:138–153

    PubMed  CAS  Google Scholar 

  • Schmidt LH (1959) Observations on the utility of isoniazid in the prophylaxis of experimental tuberculosis. Bull Int Union Tuberc 29:276–284

    Google Scholar 

  • Seelemann M, Buschkiel H, Rackow HG (1957a) Chemoprophylaktische Versuche bei Rindertuberkulose. 1. Mittlg. Zbl Vet Med 4:80–93

    Google Scholar 

  • Seelemann M, Buschkiel H, Rackow HG (1957b) Chemoprophylaktische Versuche bei Rindertuberkulose. 2. Mittlg. Zbl Vet Med 4:101–118

    Google Scholar 

  • Seelemann M, Buschkiel H, Rackow HG (1958) Chemoprophylaktische Versuche bei Rindertuberkulose. 3. Mittlg. Zbl Vet Med 5:609–628

    Google Scholar 

  • Seifert H (1962) “Chemoprophylaxe” zur Verhütung von Infektionskrankheiten bei Rindern. Vet Med Nachr 4:207

    Google Scholar 

  • Seri I, Balogh Z (1962) Zur Frage der tuberkulösen Superinfektion, II. Mitteilung. Tuberk Arzt 16:677–682

    CAS  Google Scholar 

  • Sher BC, Czaja ZG, Takimura Y, Popper H (1957) The course of experimental tuberculosis inhibited by isoniazid. Am Rev Tuberc 75:295–302

    PubMed  CAS  Google Scholar 

  • Spiess H (1959) Chemoprophylaxe und präventive Chemotherapie gegen die Tuberkulose. Dtsch Med Wochenschr 84:1410–1415

    Article  PubMed  CAS  Google Scholar 

  • Spiess H (1961) Zur Kombination von Impf-und Chemoprophylaxe der Tuberkulose. Dtsch Med Wochenschr 86:2162–2163

    Article  PubMed  CAS  Google Scholar 

  • Spiess H (1963) Tuberkulose. Chemo-und Impfprophylaxe. Hdb Kinderheilk 5:807–834

    Google Scholar 

  • Spryszak A (1961) Control of bovine tuberculosis with reference to chemoprophylaxis in calves. Bull Off Int Epizoot 56:954–958

    Google Scholar 

  • Spryszak A (1964) An accelerated restoration to health of a tuberculous herd by the preventive application of isoniazid. Bull Vet Inst Pulawy 8:44–48

    Google Scholar 

  • Tai FH, Jen TM, Chu BY, Han SH (1961) Isoniazid prophylaxis of tuberculous infection in mice. Am Rev Respir Dis 83:711–717

    PubMed  CAS  Google Scholar 

  • Teuscher E (1956) Zur Känguruhtuberkulose. Thesis, Zürich

    Google Scholar 

  • Toyohara MA, Kidoh YO, Bayashi O (1959) Studies on the effect of isoniazid upon the antituberculous immunity induced by BCG vaccination. Tubercle 40:184–191

    Article  PubMed  CAS  Google Scholar 

  • Uehlinger E, Siebenmann R, Frei H (1952) Erste Erfahrungen mit Rimifon „Roche“ bei experimenteller Meerschweinchentuberkulose. Schweiz Med Wochenschr 33:335–338

    Google Scholar 

  • Ungar J, Thomas V, Muggleton PW (1961) Freeze-dried BCG vaccine from an isoniazid resistant strain. Brit Med J 1:1498–1500

    Article  PubMed  CAS  Google Scholar 

  • Veltman T (1955) Experimentelle Untersuchungen zur Chemotherapie der Tuberkulose. 1. Mittlg. Zbl Bkt I Orig 163:177–209

    CAS  Google Scholar 

  • Veltman T (1955a) Experimentelle Untersuchungen zur Chemotherapie der Tuberkulose. 2. Mittlg. Zbl Bkt I Orig 163:210–218

    CAS  Google Scholar 

  • Veltman T (1955b) Experimentelle Untersuchungen zur Chemotherapie der Tuberkulose. 3. Mittlg. Zbl Bkt I Orig 163:484–504

    CAS  Google Scholar 

  • Vivien JN, Grosset J (1961) Le taux d’isoniazide actif dans le sérum sanguin. Adv Tuberc Res 11:45–110

    Google Scholar 

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  1. H. H. Kleeberg
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  1. Julius-Lucas-Weg 67, D-5600, Wuppertal 1, Germany

    Karl Bartmann

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Kleeberg, H.H. (1988). Experimental Evaluation of Chemoprophylaxis and Preventive Treatment in Animals. In: Bartmann, K. (eds) Antituberculosis Drugs. Handbook of Experimental Pharmacology, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72873-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-72873-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72875-4

  • Online ISBN: 978-3-642-72873-0

  • eBook Packages: Springer Book Archive

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