Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids
With few exceptions, both eukaryotic and prokaryotic cells contain high concentrations of the tripeptide γ-glutamyl-cysteinyl-glycine (glutathione; GSH) [1, 2]. Glutathione plays a number of important roles in cellular metabolism, including maintenance of the correct intracellular thiol redox balance, the enzymatic removal of hydrogen peroxide and the scavenging of free radicals. Glutathione has also been implicated in the control of DNA and protein synthesis and regulation of enzyme activity C3]. The intracellular ratio of reduced to oxidized glutathione (GSH : GSSG) is kept high (GSSG < 1% of the total) due to the presence of the NADPH-dependent enzyme, glutathione reductase [E.C. 22.214.171.124].
KeywordsCysteine Adduct Thiol Catalase Hydroperoxide
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