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Metabolism of Trypanothione and Glutathionylspermidine in Trypanosomatids

  • Alan H. Fairlamb
  • Graeme B. Henderson
Part of the NATO ASI Series book series (volume 11)

Abstract

With few exceptions, both eukaryotic and prokaryotic cells contain high concentrations of the tripeptide γ-glutamyl-cysteinyl-glycine (glutathione; GSH) [1, 2]. Glutathione plays a number of important roles in cellular metabolism, including maintenance of the correct intracellular thiol redox balance, the enzymatic removal of hydrogen peroxide and the scavenging of free radicals. Glutathione has also been implicated in the control of DNA and protein synthesis and regulation of enzyme activity C3]. The intracellular ratio of reduced to oxidized glutathione (GSH : GSSG) is kept high (GSSG < 1% of the total) due to the presence of the NADPH-dependent enzyme, glutathione reductase [E.C. 1.6.4.2].

Keywords

Glutathione Reductase Lipoic Acid Cumene Hydroperoxide Bloodstream Form Standard Redox Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Alan H. Fairlamb
    • 1
  • Graeme B. Henderson
    • 1
  1. 1.Laboratory of Medical BiochemistryRockefeller UniversityNew YorkUSA

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