Recognition processes involved in binding and ingestion of L. donovani by host macrophages

  • A. O. Wozencraft
  • J. M. Blackwell
Conference paper
Part of the NATO ASI Series book series (volume 11)

Abstract

The causal organism of visceral leishmaniasis, the protozoan parasite Leishmania donovani, displays a specific tropism for mononuclear phagocyte (MP) populations within the vertebrate host. Infection is initiated upon invasion of host MPs by the promastigote form of the parasite, following inoculation by the sandfly vector. A number of studies have been carried out to determine which receptors on the MP surface are involved in this interaction (Blackwell, 1985). Our laboratory has previously established that the complement type 3 receptor (CR3), which recognizes complement component iC3b, plays a major role in the invasion of resident murine peritoneal macrophages (RPM) in vitro by L. donovani LV9 promastigotes (Blackwell et al., 1985). These studies provided compelling evidence to suggest that opsonization of the promatigote by locally secreted, RPM-derived complement facilitates uptake via CR3 in the absence of an exogenous serum source. The presence of RPM-derived complement on the parasite surface has since been visualized by immunoelectron microscopy (Wozencraft et al., 1986).

Keywords

Trop Leishmaniasis Cytochalasin Trypanosoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • A. O. Wozencraft
  • J. M. Blackwell
    • 1
  1. 1.Department of Tropical HygieneLondon School of Hygiene and Tropical MedicineLondonUK

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