Skip to main content

The Roles of Surface Membrane Enzymes and Transporters in the Survival of Leishmania

  • Conference paper
Host-Parasite Cellular and Molecular Interactions in Protozoal Infections

Part of the book series: NATO ASI Series ((ASIH,volume 11))

Abstract

The means by which Leishmania survive within their several hosts remain unknown. However, as their surface membrane interfaces with host environments, it must fulfill numerous vital functions requisite for maintaining the parasite. Thus, knowledge of the biochemistry and physiology of these membranes is relevant to defining the mechanisms of parasite survival. This topic has been reviewed recently (Dwyer & Gottlieb, 1983, 1985) and the current report concerns some recent advances in this area.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Das S, Saha AK, Remaiey AT, Glew RH, Dowling JN, Kajiyoshi M, Gottlieb M (1986) Hydrolysis of phosphoproteins and inositol phosphates by cell surface phosphatase of Leishmania donovani. Mol Biochem Parasitol 20: 143–153

    Article  PubMed  CAS  Google Scholar 

  • Dwyer DM, Gottlieb M (1983) The surface membrane chemistry of Leishmania: its possible role in parasite sequestration and survival. J Cell Biochem 23: 35–45

    Article  PubMed  CAS  Google Scholar 

  • Dwyer DM, Gottlieb M (1985) The biochemistry of Lesihmania surface membranes. In: Chang K-P, Bray RS (eds) Leishmaniasis. Elsevier, Amsterdam New York Oxford, p 31

    Google Scholar 

  • Etges R, Bouvier J, Bordier C (1986) The major surface protein of Leishmania promastigotes is a protease. J Biol Chem 261: 9098–9101

    PubMed  CAS  Google Scholar 

  • Gottlieb M (1985) Enzyme regulation in a trypanosomatid: effect of purine starvation on levels of 31-nucleotidase activity. Science 227: 72–74

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb M, Zlotnick GW (1986) 3’-nucleotidase of Leishmania donovani-evidence for exonuclease activity. In:Agabian N, Goodman H, Noguiera, N (eds) Molecular strategies of parasitic invasion. UCLA Symposia on Molecular and Cellular Biology, New Series. Vol. 42, Alan R. Liss Inc., New York

    Google Scholar 

  • Remaley AT, Glew RH, Kuhns DB, Basford RE, Waggoner AS, Ernst LA, Pope MB (1985) Leishmania donovani: surface membrane acid phosphatase blocks neutrophil oxidative metabolite production. Exp Parasitol 60: 331–341

    Google Scholar 

  • Saha AK,, Das S, Glew RH, Gottlieb M (1985) Resistance of leishmanial phosphatases to inactivation by oxygen metabolites. J Clin Microbiol 22: 329–332

    Google Scholar 

  • Wassef MK, Fioretti TB, Dwyer DM (1985) Lipid analyses of isolated surface membranes of Leishmania donovani promastigotes. Lipids 20: 108–115

    Article  PubMed  CAS  Google Scholar 

  • Zilberstein D, Dwyer DM (1984a) Glucose transport in Leishmania donovani promastigotes. Mol Biochem Parasitol 12: 327 - 336

    Article  PubMed  CAS  Google Scholar 

  • Zilberstein D, Dwyer DM (1984b) Antidepressants cause lethal disruption of membrane function in the human protozoan parasite Leishmania. Science 226: 977–979

    Article  PubMed  CAS  Google Scholar 

  • Zilberstein D, Dwyer DM (1985) Proton motive force-driven active transport of D-glucose and L-proline in the protozoan parasite Leishmania donovani. Proc Natl Acad Sci USA 82: 1716–1720

    Article  PubMed  CAS  Google Scholar 

  • Zilberstein D, Dwyer DM, Matthaei S, Horuk R (to be published) Identification and biochemical characterization of the plasma membrane glucose transporter of Leishmania donovani. J Biol Chem

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Dwyer, D.M. (1987). The Roles of Surface Membrane Enzymes and Transporters in the Survival of Leishmania . In: Chang, KP., Snary, D. (eds) Host-Parasite Cellular and Molecular Interactions in Protozoal Infections. NATO ASI Series, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72840-2_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72840-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72842-6

  • Online ISBN: 978-3-642-72840-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics